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1xz9
From Proteopedia
(Difference between revisions)
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==Structure of AF-6 PDZ domain== | ==Structure of AF-6 PDZ domain== | ||
| - | <StructureSection load='1xz9' size='340' side='right'caption='[[1xz9 | + | <StructureSection load='1xz9' size='340' side='right'caption='[[1xz9]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1xz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1xz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XZ9 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xz9 OCA], [https://pdbe.org/1xz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xz9 RCSB], [https://www.ebi.ac.uk/pdbsum/1xz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xz9 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xz9 OCA], [https://pdbe.org/1xz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xz9 RCSB], [https://www.ebi.ac.uk/pdbsum/1xz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xz9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein. | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Boisguerin | + | [[Category: Boisguerin P]] |
| - | [[Category: Joshi | + | [[Category: Joshi M]] |
| - | [[Category: Krause | + | [[Category: Krause G]] |
| - | [[Category: Leitner | + | [[Category: Leitner D]] |
| - | [[Category: Moelling | + | [[Category: Moelling K]] |
| - | [[Category: Oschkinat | + | [[Category: Oschkinat H]] |
| - | [[Category: Schade | + | [[Category: Schade M]] |
| - | [[Category: Schmieder | + | [[Category: Schmieder P]] |
| - | [[Category: Volkmer-Engert | + | [[Category: Volkmer-Engert R]] |
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Current revision
Structure of AF-6 PDZ domain
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