Corticosteroids

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(New page: <StructureSection load='' size='350' side='right' caption='FMN containing pentaerythritol tetranitrate reductase complex with prednisone (PDB entry 1h61)' scene='49/490063/Cv/1'> This ...)
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<StructureSection load='' size='350' side='right' caption='FMN containing pentaerythritol tetranitrate reductase complex with prednisone (PDB entry [[1h61]])' scene='49/490063/Cv/1'>
<StructureSection load='' size='350' side='right' caption='FMN containing pentaerythritol tetranitrate reductase complex with prednisone (PDB entry [[1h61]])' scene='49/490063/Cv/1'>
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This is a default text for your page '''Corticosteroids'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, [[glucocorticoids]] and [[mineralocorticoids]], are involved in a wide range of physiological processes.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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== Function ==
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<scene name='89/896210/Cv/1'>Prednisone</scene> and its derivatives have some mineralocorticoid action in addition to the glucocorticoid effect.
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== Disease ==
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<scene name='89/895670/Cv/2'>Cortisol</scene> (hydrocortisone) is a corticosteroid with both glucocorticoid and mineralocorticoid activity and effects.
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== Relevance ==
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<scene name='89/895670/Cv/3'>Dexamethasone</scene> is a glucocorticoid medication. It is the most potent glucocorticoid and it has not mineralocorticoid potency. <scene name='89/895670/Cv/4'>Human glucocorticoid receptor ligand-binding domain bound to dexamethasone</scene> ([[1m2z]]).
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*[[Glucocorticoids]]
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== Structural highlights ==
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*[[Mineralocorticoids]]
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*[[Pentaerythritol tetranitrate reductase]] active site contains the cofactor <scene name='49/490063/Cv/5'>FMN</scene> and the <scene name='49/490063/Cv/6'>substrate steroid prednisone</scene><ref>PMID:11428899</ref>. Water molecules are shown as red spheres. <scene name='49/490063/Cv/7'>Whole active site</scene>.
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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*[[Corticosteroid-binding globulin]]
</StructureSection>
</StructureSection>
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See also:
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*[[Steroid Hormones and their receptors]]
== References ==
== References ==
<references/>
<references/>

Current revision

FMN containing pentaerythritol tetranitrate reductase complex with prednisone (PDB entry 1h61)

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See also:

References

  1. ↑ Barna TM, Khan H, Bruce NC, Barsukov I, Scrutton NS, Moody PC. Crystal structure of pentaerythritol tetranitrate reductase: "flipped" binding geometries for steroid substrates in different redox states of the enzyme. J Mol Biol. 2001 Jul 6;310(2):433-47. PMID:11428899 doi:10.1006/jmbi.2001.4779

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky

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