Corticosteroids
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<StructureSection load='' size='350' side='right' caption='FMN containing pentaerythritol tetranitrate reductase complex with prednisone (PDB entry [[1h61]])' scene='49/490063/Cv/1'> | <StructureSection load='' size='350' side='right' caption='FMN containing pentaerythritol tetranitrate reductase complex with prednisone (PDB entry [[1h61]])' scene='49/490063/Cv/1'> | ||
| - | Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes. | + | Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, [[glucocorticoids]] and [[mineralocorticoids]], are involved in a wide range of physiological processes. |
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| + | <scene name='89/896210/Cv/1'>Prednisone</scene> and its derivatives have some mineralocorticoid action in addition to the glucocorticoid effect. | ||
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| + | <scene name='89/895670/Cv/2'>Cortisol</scene> (hydrocortisone) is a corticosteroid with both glucocorticoid and mineralocorticoid activity and effects. | ||
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| + | <scene name='89/895670/Cv/3'>Dexamethasone</scene> is a glucocorticoid medication. It is the most potent glucocorticoid and it has not mineralocorticoid potency. <scene name='89/895670/Cv/4'>Human glucocorticoid receptor ligand-binding domain bound to dexamethasone</scene> ([[1m2z]]). | ||
| + | *[[Glucocorticoids]] | ||
| + | *[[Mineralocorticoids]] | ||
*[[Pentaerythritol tetranitrate reductase]] active site contains the cofactor <scene name='49/490063/Cv/5'>FMN</scene> and the <scene name='49/490063/Cv/6'>substrate steroid prednisone</scene><ref>PMID:11428899</ref>. Water molecules are shown as red spheres. <scene name='49/490063/Cv/7'>Whole active site</scene>. | *[[Pentaerythritol tetranitrate reductase]] active site contains the cofactor <scene name='49/490063/Cv/5'>FMN</scene> and the <scene name='49/490063/Cv/6'>substrate steroid prednisone</scene><ref>PMID:11428899</ref>. Water molecules are shown as red spheres. <scene name='49/490063/Cv/7'>Whole active site</scene>. | ||
| + | *[[Corticosteroid-binding globulin]] | ||
</StructureSection> | </StructureSection> | ||
| + | See also: | ||
| + | *[[Steroid Hormones and their receptors]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
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See also:
References
- ↑ Barna TM, Khan H, Bruce NC, Barsukov I, Scrutton NS, Moody PC. Crystal structure of pentaerythritol tetranitrate reductase: "flipped" binding geometries for steroid substrates in different redox states of the enzyme. J Mol Biol. 2001 Jul 6;310(2):433-47. PMID:11428899 doi:10.1006/jmbi.2001.4779
