We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
7vtw
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7vtw is ON HOLD Authors: Wu, X.-N., Zhou, Q., Huang, Y.-D., Li, Z., Wu, Y., Luo, H.-B. Description: Crystal structure of PDE8A catalytic domain in ...) |
|||
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of PDE8A catalytic domain in complex with 17== | |
| + | <StructureSection load='7vtw' size='340' side='right'caption='[[7vtw]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7vtw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VTW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7997134Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=807:9-[[3-[2,2-bis(fluoranyl)ethoxy]-5-propan-2-yloxy-phenyl]methyl]-2-chloranyl-purin-6-amine'>807</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vtw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vtw OCA], [https://pdbe.org/7vtw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vtw RCSB], [https://www.ebi.ac.uk/pdbsum/7vtw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vtw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDE8A_HUMAN PDE8A_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.<ref>PMID:18983167</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Huang | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Wu | + | [[Category: Huang Y-D]] |
| - | [[Category: | + | [[Category: Li Z]] |
| + | [[Category: Luo H-B]] | ||
| + | [[Category: Wu X-N]] | ||
| + | [[Category: Wu Y]] | ||
| + | [[Category: Zhou Q]] | ||
Current revision
Crystal structure of PDE8A catalytic domain in complex with 17
| |||||||||||
Categories: Homo sapiens | Large Structures | Huang Y-D | Li Z | Luo H-B | Wu X-N | Wu Y | Zhou Q
