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3kls

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<StructureSection load='3kls' size='340' side='right'caption='[[3kls]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
<StructureSection load='3kls' size='340' side='right'caption='[[3kls]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3kls]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staar Staar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KLS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3kls]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MRSA252 Staphylococcus aureus subsp. aureus MRSA252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KLS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cu7|3cu7]], [[2qej|2qej]], [[3km9|3km9]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kls OCA], [https://pdbe.org/3kls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kls RCSB], [https://www.ebi.ac.uk/pdbsum/3kls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kls ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kls OCA], [https://pdbe.org/3kls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kls RCSB], [https://www.ebi.ac.uk/pdbsum/3kls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kls ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:[https://omim.org/entry/609536 609536]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).
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[https://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN] Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:[https://omim.org/entry/609536 609536]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
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[https://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN] Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/3kls_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/3kls_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Staar]]
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[[Category: Staphylococcus aureus subsp. aureus MRSA252]]
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[[Category: Andersen, G R]]
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[[Category: Andersen GR]]
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[[Category: Bjerre, M]]
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[[Category: Bjerre M]]
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[[Category: Christensen, J B]]
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[[Category: Christensen JB]]
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[[Category: Fraser, J D]]
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[[Category: Fraser JD]]
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[[Category: Fredslund, F]]
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[[Category: Fredslund F]]
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[[Category: Gordon, N]]
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[[Category: Gordon N]]
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[[Category: Hermans, S]]
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[[Category: Hermans S]]
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[[Category: Jackson, N]]
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[[Category: Jackson N]]
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[[Category: Jensen, M]]
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[[Category: Jensen M]]
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[[Category: Laursen, N S]]
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[[Category: Laursen NS]]
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[[Category: Lorenz, N]]
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[[Category: Lorenz N]]
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[[Category: Sottrup-Jensen, L]]
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[[Category: Sottrup-Jensen L]]
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[[Category: Spillner, E]]
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[[Category: Spillner E]]
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[[Category: Wines, B]]
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[[Category: Wines B]]
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[[Category: B-grasp domain]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Complement alternate pathway]]
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[[Category: Complement pathway]]
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[[Category: Cytolysis]]
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[[Category: Disulfide bond]]
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[[Category: Fn3 domain]]
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[[Category: Glycoprotein]]
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[[Category: Immune response]]
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[[Category: Immune system]]
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[[Category: Inflammatory response]]
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[[Category: Innate immunity]]
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[[Category: Membrane attack complex]]
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[[Category: Ob-fold]]
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[[Category: Secreted]]
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Current revision

Structure of complement C5 in complex with SSL7

PDB ID 3kls

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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