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2kym

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Current revision (06:50, 1 May 2024) (edit) (undo)
 
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==Solution structure of the Bem1p SH3-CI domain from L.elongisporus in complex with Ste20p peptide==
==Solution structure of the Bem1p SH3-CI domain from L.elongisporus in complex with Ste20p peptide==
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<StructureSection load='2kym' size='340' side='right'caption='[[2kym]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2kym' size='340' side='right'caption='[[2kym]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2kym]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lodel Lodel]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KYM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2kym]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lodderomyces_elongisporus_NRRL_YB-4239 Lodderomyces elongisporus NRRL YB-4239] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KYM FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LELG_04233 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=379508 LODEL])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kym OCA], [https://pdbe.org/2kym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kym RCSB], [https://www.ebi.ac.uk/pdbsum/2kym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kym ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kym OCA], [https://pdbe.org/2kym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kym RCSB], [https://www.ebi.ac.uk/pdbsum/2kym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kym ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/STE20_YEAST STE20_YEAST]] MAP4K component of the MAPK pathway required for the mating pheromone response, haploid invasive growth and diploid pseudohyphal development. Links the pheromone response G-protein beta gamma subunits to downstream signaling components. Needed for mating in haploid cells, induction of a mating-specific gene FUS1, induction of mating-specific morphologies, and pheromone-induced proliferation arrest. Required for the regulation of the actin polarization and bud emergence during cell cycle in G1. Involved in the high osmolarity glycerol (HOG) response. Phosphorylates 'Thr-307' and 'Ser-302' or 'Ser-306' of STE11 and 'Ser-357' of MYO3. Phosphorylates histone H2B to form H2BS10ph during meiosis and H(2)O(2)-induced apoptosis. Its interaction with CDC42 is required for both invasive growth and the formation of pseudohyphae. Its interaction with STE4 is required for the pheromone signaling.<ref>PMID:1464311</ref> <ref>PMID:8421676</ref> <ref>PMID:7608157</ref> <ref>PMID:9003780</ref> <ref>PMID:8722766</ref> <ref>PMID:8643578</ref> <ref>PMID:9009270</ref> <ref>PMID:9388196</ref> <ref>PMID:9742399</ref> <ref>PMID:9428767</ref> <ref>PMID:10562285</ref> <ref>PMID:10837245</ref> <ref>PMID:10970855</ref> <ref>PMID:11003652</ref> <ref>PMID:11940652</ref> <ref>PMID:12686605</ref> <ref>PMID:12588977</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15743816</ref>
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[https://www.uniprot.org/uniprot/A5E3P5_LODEL A5E3P5_LODEL]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kym ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kym ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lodel]]
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[[Category: Lodderomyces elongisporus NRRL YB-4239]]
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[[Category: Davidson, A R]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Gorelik, M]]
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[[Category: Davidson AR]]
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[[Category: Muhandiram, R]]
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[[Category: Gorelik M]]
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[[Category: Bem1p]]
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[[Category: Muhandiram R]]
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[[Category: Cdc42p-interacting]]
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[[Category: Scaffold]]
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[[Category: Sh3 domain]]
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[[Category: Sh3-ci]]
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[[Category: Signaling protein]]
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[[Category: Ste20p prr]]
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Current revision

Solution structure of the Bem1p SH3-CI domain from L.elongisporus in complex with Ste20p peptide

PDB ID 2kym

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