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2l6a

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==Three-dimensional structure of the N-terminal effector PYRIN domain of NLRP12==
==Three-dimensional structure of the N-terminal effector PYRIN domain of NLRP12==
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<StructureSection load='2l6a' size='340' side='right'caption='[[2l6a]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2l6a' size='340' side='right'caption='[[2l6a]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l6a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L6A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l6a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L6A FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NLRP12, NALP12, PYPAF7, RNO ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l6a OCA], [https://pdbe.org/2l6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l6a RCSB], [https://www.ebi.ac.uk/pdbsum/2l6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l6a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l6a OCA], [https://pdbe.org/2l6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l6a RCSB], [https://www.ebi.ac.uk/pdbsum/2l6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l6a ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/NAL12_HUMAN NAL12_HUMAN]] NLRP12-associated hereditary periodic fever syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/NAL12_HUMAN NAL12_HUMAN] NLRP12-associated hereditary periodic fever syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NAL12_HUMAN NAL12_HUMAN]] May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
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[https://www.uniprot.org/uniprot/NAL12_HUMAN NAL12_HUMAN] May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Peti, W]]
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[[Category: Peti W]]
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[[Category: Pinheiro, A S]]
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[[Category: Pinheiro AS]]
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[[Category: Death domain]]
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[[Category: Nlrp12]]
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[[Category: Pyrin]]
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[[Category: Signaling protein]]
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Current revision

Three-dimensional structure of the N-terminal effector PYRIN domain of NLRP12

PDB ID 2l6a

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