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Mitogen-activated protein kinase 3D structures

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Current revision (11:37, 29 December 2025) (edit) (undo)
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
-
*MAPK1 or ERK2
+
*MAPK1 or Erk2
**[[4g6n]], [[4g6o]], [[4gsb]] – hMAPK1 - human<br />
**[[4g6n]], [[4g6o]], [[4gsb]] – hMAPK1 - human<br />
-
**[[6d5y]] – hMAPK1 (mutant)<br />
+
**[[6d5y]], [[7e73]], [[7e75]], [[8rlx]], [[8rmb]] – hMAPK1 (mutant)<br />
**[[6rfo]] – hMAPK1/MAPK14 peptide<br />
**[[6rfo]] – hMAPK1/MAPK14 peptide<br />
-
**[[3i5z]], [[3i60]], [[3w55]], [[2ojg]], [[2oji]], [[2ojj]], [[1wzy]], [[1tvo]], [[3sa0]], [[4fux]], [[4fuy]], [[4fv0]], [[4fv1]], [[4fv2]], [[4fv3]], [[4fv4]], [[4fv5]], [[4fv6]], [[4fv7]], [[4fv8]], [[4fv9]], [[4n4s]], [[4o6e]], [[4qp1]], [[4qp2]], [[4qp3]], [[4qp4]], [[4qp6]], [[4qp7]], [[4qp8]], [[4qp9]] [[4qpa]], [[4qta]], [[4qte]], [[4xj0]], [[4xne]], [[4xoy]], [[4xoz]], [[4xp0]], [[4xp2]], [[4xp3]], [[4xrj]], [[4xrl]], [[4zzm]], [[4zzn]], [[4zzo]], [[5bue]], [[5bui]], [[5buj]], [[5bvd]], [[5bve]], [[5bvf]], [[5hd4]], [[5hd7]], [[5k4i]], [[5ke0]], [[5lcj]], [[5lck]], [[5ngu]], [[5nhf]], [[5nhh]], [[5nhj]], [[5nhl]], [[5nho]], [[5nhp]], [[5nhv]], [[5u6i]], [[5wp1]], [[6dmg]], [[6g8x]], [[6g91]], [[6g92]], [[6g93]], [[6g97]], [[6g9a]], [[6g9d]], [[6g9h]], [[6g9j]], [[6g9k]], [[6g9m]], [[6g9n]], [[6dcg]], [[6gjd]], [[6gjb]], [[6ge0]], [[6gdq]], [[6gdm]], [[6g9n]], [[6g54]], [[6nbs]], [[6oph]], [[6opi]], [[6qaw]], [[6qaq]], [[6qal]], [[6qah]], [[6qag]], [[6qa4]], [[6qa3]], [[6qa1]], [[6q7t]], [[6q7s]], [[6q7k]], [[6rq4]], [[7auv]], [[7nqq]], [[7nqw]], [[7nr3]], [[7nr5]], [[7nr8]], [[7nr9]] – hMAPK1+inhibitor - human<br />
+
**[[1tvo]], [[1wzy]], [[2ojg]], [[2oji]], [[2ojj]], [[3i5z]], [[3i60]], [[3sa0]], [[3w55]], [[4fux]], [[4fuy]], [[4fv0]], [[4fv1]], [[4fv2]], [[4fv3]], [[4fv4]], [[4fv5]], [[4fv6]], [[4fv7]], [[4fv8]], [[4fv9]], [[4n4s]], [[4o6e]], [[4qp1]], [[4qp2]], [[4qp3]], [[4qp4]], [[4qp6]], [[4qp7]], [[4qp8]], [[4qp9]] [[4qpa]], [[4qta]], [[4qte]], [[4xj0]], [[4xne]], [[4xoy]], [[4xoz]], [[4xp0]], [[4xp2]], [[4xp3]], [[4xrj]], [[4xrl]], [[4zzm]], [[4zzn]], [[4zzo]], [[5bue]], [[5bui]], [[5buj]], [[5bvd]], [[5bve]], [[5bvf]], [[5hd4]], [[5hd7]], [[5k4i]], [[5ke0]], [[5lcj]], [[5lck]], [[5ngu]], [[5nhf]], [[5nhh]], [[5nhj]], [[5nhl]], [[5nho]], [[5nhp]], [[5nhv]], [[5u6i]], [[5wp1]], [[6dcg]], [[6dmg]], [[6g54]], [[6g8x]], [[6g91]], [[6g92]], [[6g93]], [[6g97]], [[6g9a]], [[6g9d]], [[6g9h]], [[6g9j]], [[6g9k]], [[6g9m]], [[6g9n]], [[6g9n]], [[6gdq]], [[6gdm]], [[6ge0]], [[6gjd]], [[6gjb]], [[6nbs]], [[6oph]], [[6opi]], [[6q7k]], [[6q7s]], [[6q7t]], [[6qa1]], [[6qa3]], [[6qa4]], [[6qag]], [[6qah]], [[6qal]], [[6qaq]], [[6qaw]], [[6rq4]], [[7auv]], [[7nqq]], [[7nqw]], [[7nr3]], [[7nr5]], [[7nr8]], [[7nr9]], [[7w5o]], [[7x4u]], [[7xc1]], [[8ao2]], [[8ao3]], [[8ao4]], [[8ao5]], [[8ao6]], [[8ao7]], [[8ao8]], [[8ao9]], [[8aoa]], [[8aob]], [[8aoc]], [[8aod]], [[8aoe]], [[8aof]], [[8aog]], [[8aoh]], [[8aoi]], [[8aoj]], [[8zjv]], [[9lnr]] – hMAPK1+inhibitor - human<br />
 +
**[[8u8j]], [[8u8k]] – hMAPK1 (mutant) +inhibitor <br />
 +
**[[8pst]], [[8psw]], [[8psy]], [[8pt0]], [[8pt1]], [[8pt3]], [[8pt5]], [[8r5f]] – hMAPK1+ cyclohexanone-based inhibitor <br />
**[[2y9q]] – hMAPK1 + MAP kinase-interacting Ser/Thr protein kinase peptide<br />
**[[2y9q]] – hMAPK1 + MAP kinase-interacting Ser/Thr protein kinase peptide<br />
**[[3tei]], [[4h3p]], [[4nif]] – hMAPK1 (mutant) + ribosomal protein S6 kinase α-1<br />
**[[3tei]], [[4h3p]], [[4nif]] – hMAPK1 (mutant) + ribosomal protein S6 kinase α-1<br />
**[[4iz5]], [[4iz7]], [[4iza]] – hMAPK1 (mutant) + astrocytic phosphoprotein <br />
**[[4iz5]], [[4iz7]], [[4iza]] – hMAPK1 (mutant) + astrocytic phosphoprotein <br />
**[[4fmq]] – hMAPK1 + MAPK docking peptide<br />
**[[4fmq]] – hMAPK1 + MAPK docking peptide<br />
-
**[[5v62]], [[5v61]], [[6slg]] – hMAPK1 + ERK2 peptide + inhibitor<br />
+
**[[5v61]], [[5v62]], [[6slg]] – hMAPK1 + ERK2 peptide + inhibitor<br />
**[[4h3q]] – hMAPK1 + MAP2K 2 peptide<br />
**[[4h3q]] – hMAPK1 + MAP2K 2 peptide<br />
 +
**[[8pvu]] – hMAPK1 + deoxyhypusine synthase<br />
 +
**[[8psr]] – hMAPK1 + peptide<br />
**[[5ax3]] – hMAPK1 + allosteric inhibitor peptide<br />
**[[5ax3]] – hMAPK1 + allosteric inhibitor peptide<br />
 +
**[[7opm]] – hMAPK1 + inhibitor peptide + ORF45<br />
**[[4n0s]] – hMAPK1 + cafeic acid<br />
**[[4n0s]] – hMAPK1 + cafeic acid<br />
**[[4zxt]] – hMAPK1 + catechol<br />
**[[4zxt]] – hMAPK1 + catechol<br />
 +
**[[8qr2]], [[8qr3]], [[8qr4]], [[8qr5]], [[8qr6]], [[8qr7]], [[8qr8]], [[8qr9]], [[8qra]], [[8qrb]], [[8qrc]] – hMAPK1 + macrocyclic ligand<br />
**[[5v60]] – hMAPK1 + ACP<br />
**[[5v60]] – hMAPK1 + ACP<br />
**[[6opg]] – hMAPK1 + AMPPNP<br />
**[[6opg]] – hMAPK1 + AMPPNP<br />
-
**[[1erk]], [[4s31]], [[5umo]] - rMAPK1 - rat<br />
+
**[[8rqv]], [[8rqw]], [[8rqx]] – hMAPK1 (mutant) + AMPPNP<br />
-
**[[1gol]], [[3r63]], [[4s2z]], [[4s30]], [[6rfp]] - rMAPK1 (mutant)<br />
+
**[[5umo]], [[4s31]] - rMAPK1 - rat<br />
-
**[[2z7l]], [[3c9w]], [[3qyw]], [[3qyz]], [[4qyy]], [[6cpw]], [[6opk]], [[6opi]], [[6oph]], [[6fxv]], [[6frp]], [[6fr1]], [[6fq7]], [[6fn5]], [[6fma]], [[6flv]], [[6fle]], [[6fjz]], [[6fjb]], [[6fj0]], [[6fi6]], [[6fi3]] - rMAPK1+inhibitor <br />
+
**[[1gol]], [[3r63]], [[4s2z]], [[4s30]], [[6rfp]], [[8rm2]] - rMAPK1 (mutant)<br />
 +
**[[2z7l]], [[3c9w]], [[3qyw]], [[3qyz]], [[4qyy]], [[6cpw]], [[6fi3]], [[6fi6]], [[6fj0]], [[6fjb]], [[6fjz]], [[6fle]], [[6flv]], [[6fma]], [[6fn5]], [[6fq7]], [[6fr1]], [[6frp]], [[6fxv]], [[6oph]], [[6opi]], [[6opk]] - rMAPK1+inhibitor <br />
**[[2gph]] - rMAPK1 (mutant)+HEPTP (mutant)<br />
**[[2gph]] - rMAPK1 (mutant)+HEPTP (mutant)<br />
**[[3o71]] - rMAPK1 + colorectal cancer peptide<br />
**[[3o71]] - rMAPK1 + colorectal cancer peptide<br />
**[[2fys]] - rMAPK1 + KIM peptide<br />
**[[2fys]] - rMAPK1 + KIM peptide<br />
 +
**[[7ugb]] - rMAPK1 + ISG20 peptide<br />
**[[4s32]] – rMAPK1 + AMPPNP<br />
**[[4s32]] – rMAPK1 + AMPPNP<br />
**[[4s33]], [[4s34]] – rMAPK1 (mutant) + AMPPNP<br />
**[[4s33]], [[4s34]] – rMAPK1 (mutant) + AMPPNP<br />
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**[[1kwp]] – hMAPK2<br />
**[[1kwp]] – hMAPK2<br />
**[[3gok]] - hMAPK2 kinase domain<br />
**[[3gok]] - hMAPK2 kinase domain<br />
-
**[[2pzy]], [[2p3g]], [[2jbo]], [[2jbp]] – hMAPK2 kinase domain +inhibitor<br />
+
**[[2jbo]], [[2jbp]], [[2p3g]], [[2pzy]] – hMAPK2 kinase domain +inhibitor<br />
-
**[[3a2c]], [[3kc3]], [[3fpm]], [[3fyj]], [[3fyk]], [[3r2b]], [[3r2y]], [[3r30]], [[3wi6]] - hMAPK2 kinase domain +inhibitor<br />
+
**[[3a2c]], [[3fpm]], [[3fyj]], [[3fyk]], [[3kc3]], [[3r2b]], [[3r2y]], [[3r30]], [[3wi6]] - hMAPK2 kinase domain +inhibitor<br />
-
**[[3m2w]], [[3kga]], [[3ka0]], [[3m42]] – hMAPK2 kinase domain (mutant)+inhibitor<br />
+
**[[3ka0]], [[3kga]], [[3m2w]], [[3m42]] – hMAPK2 kinase domain (mutant)+inhibitor<br />
-
**[[2oza]], [[2onl]] – hMAPK2+ hMAPK14<br />
+
**[[2oza]] – hMAPK2+ hMAPK14<br />
**[[4tyh]], [[6tca]] - hMAPK2+ hMAPK14 + inhibitor<br />
**[[4tyh]], [[6tca]] - hMAPK2+ hMAPK14 + inhibitor<br />
**[[1nxk]] – hMAPK2 + staurosporine<br />
**[[1nxk]] – hMAPK2 + staurosporine<br />
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**[[3erk]], [[4erk]] – rMAPK2+inhibitor<br />
**[[3erk]], [[4erk]] – rMAPK2+inhibitor<br />
-
*MAPK3 or ERK1
+
*MAPK3 or Erk1
**[[2zoq]] – hMAPK3<br />
**[[2zoq]] – hMAPK3<br />
-
**[[3r1n]], [[3she]], [[4qtb]], [[3fxw]], [[3fhr]], [[6ges]] – hMAPK3 kinase domain +inhibitor<br />
+
**[[3fhr]], [[3fxw]], [[3r1n]], [[3she]], [[4qtb]], [[6ges]] – hMAPK3 kinase domain +inhibitor<br />
 +
*MAPK4
 +
**[[7w5c]] – AtMAPK4 residues 18-372 + MAP2K peptide – ''Arabidopsis thaliana''<br />
 +
*MAPK5
 +
**[[9bu4]] – hMAPK5 (mutant) 320-466 + inhibitor<br />
-
*MAPK6 or ERK3
+
*MAPK6 or Erk3
**[[7aqb]] – hMAPK6<br />
**[[7aqb]] – hMAPK6<br />
**[[6yky]], [[6ylc]], [[6yll]] – hMAPK6 kinase domain +inhibitor<br />
**[[6yky]], [[6ylc]], [[6yll]] – hMAPK6 kinase domain +inhibitor<br />
-
**[[6dtl]] – MAPK6 residues 32-395 – ''Arabidopsis thaliana''<br />
+
**[[6dtl]] – AtMAPK6 residues 32-395 <br />
-
*MAPK7 or ERK5 kinase domain
+
*MAPK7 or Erk5 kinase domain
**[[4ic8]] – hMAPK7<br />
**[[4ic8]] – hMAPK7<br />
-
**[[4b99]], [[4zsg]], [[4zsj]], [[4zsl]], [[5byy]], [[5byz]], [[5o7i]], [[6hkn]], [[6hkm]] – hMAPK7+inhibitor<br />
+
**[[4b99]], [[4zsg]], [[4zsj]], [[4zsl]], [[5byy]], [[5byz]], [[5o7i]], [[6hkm]], [[6hkn]], [[7pus]], [[9lta]] – hMAPK7+inhibitor<br />
**[[4ic7]] – hMAPK7+ MAP2K 5<br />
**[[4ic7]] – hMAPK7+ MAP2K 5<br />
*MAPK8 or JNK1
*MAPK8 or JNK1
-
**[[3o17]], [[2gmx]], [[2g01]], [[3vud]], [[3vug]], [[3vuh]], [[3vui]], [[3vuk]], [[3vul]], [[3vum]] – hMAPK8 (mutant)+JIP1 peptide<br />
+
**[[8x5m]] - hMAPK8 JNK1 <br />
-
**[[1ukh]], [[1uki]] - jMAPK8 JNK1+JIP1 peptide<br />
+
**[[2g01]], [[2gmx]], [[3o17]], [[3vud]], [[3vug]], [[3vuh]], [[3vui]], [[3vuk]], [[3vul]], [[3vum]] – hMAPK8 (mutant)+JIP1 peptide<br />
 +
**[[1ukh]], [[1uki]], [[9ft9]] - jMAPK8 JNK1+JIP1 peptide<br />
**[[6f5e]] - hMAPK8 JNK1+JIP1 peptide + darpin<br />
**[[6f5e]] - hMAPK8 JNK1+JIP1 peptide + darpin<br />
**[[5lw1]] - hMAPK8 JNK1+JIP1 peptide + darpin + pepstatin<br />
**[[5lw1]] - hMAPK8 JNK1+JIP1 peptide + darpin + pepstatin<br />
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**[[4yr8]] – hMAPK8 + MKP7 <br />
**[[4yr8]] – hMAPK8 + MKP7 <br />
**[[3elj]], [[3pze]], [[4awi]], [[4l7f]], [[4qtd]] - hMAPK8+inhibitor<br />
**[[3elj]], [[3pze]], [[4awi]], [[4l7f]], [[4qtd]] - hMAPK8+inhibitor<br />
 +
**[[8pt8]], [[8pt9]], [[8pta]], [[8r5e]] - hMAPK8+ cyclohexanone-based inhibitor<br />
**[[4e73]], [[4g1w]], [[4hys]], [[4hyu]], [[4izy]] – hMAPK8 + JIP1 +inhibitor<br />
**[[4e73]], [[4g1w]], [[4hys]], [[4hyu]], [[4izy]] – hMAPK8 + JIP1 +inhibitor<br />
-
**[[2no3]], [[2h96]] – hMAPK8 (mutant)+inhibitor<br />
+
**[[2h96]], [[2no3]] – hMAPK8 (mutant)+inhibitor<br />
*MAPK9 or JNK2
*MAPK9 or JNK2
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**[[3e7o]], [[7cml]] - hMAPK9 (mutant)<br />
**[[3e7o]], [[7cml]] - hMAPK9 (mutant)<br />
**[[3npc]] – hMAPK9 (mutant)+inhibitor<br />
**[[3npc]] – hMAPK9 (mutant)+inhibitor<br />
 +
**[[7n8t]] – hMAPK9 + AMP<br />
*MAPK10 or JNK3
*MAPK10 or JNK3
-
**[[3kvx]], [[3fv8]], [[2waj]], [[3fi2]], [[3fi3]], [[3da6]], [[2zdt]], [[2zdu]], [[3cgf]], [[3cgo]], [[2r9s]], [[2o0u]], [[2o2u]], [[2exc]], [[2b1p]], [[1pmn]], [[4z9l]], [[1pmu]], [[1pmv]], [[3oy1]], [[2ok1]], [[3ttj]], [[3tti]], [[3rtp]], [[3v6r]], [[3v6s]], [[4kkh]], [[4u79]], [[4whz]], [[4x21]], [[4y46]], [[4y5h]], [[3g9l]], [[3g90]], [[3g9n]], [[2p33]], [[6emh]], [[6ekd]], [[7ksi]], [[7ksj]], [[7ksk]], [[7ore]], [[7orf]], [[7s1n]] – hMAPK10 catalytic domain + inhibitor<br />
+
**[[8wgf]] – hMAPK10 catalytic domain <br />
 +
**[[1pmn]], [[1pmu]], [[1pmv]], [[2b1p]], [[2exc]], [[2o0u]], [[2o2u]], [[2ok1]], [[2p33]], [[2r9s]], [[2waj]], [[2zdt]], [[2zdu]], [[3cgf]], [[3cgo]], [[3da6]], [[3fi2]], [[3fi3]], [[3fv8]], [[3g90]], [[3g9l]], [[3g9n]], [[3kvx]], [[3oy1]], [[3rtp]], [[3tti]], [[3ttj]], [[3v6r]], [[3v6s]], [[4kkh]], [[4u79]], [[4whz]], [[4x21]], [[4y46]], [[4y5h]], [[4z9l]], [[6ekd]], [[6emh]], [[7ksi]], [[7ksj]], [[7ksk]], [[7ore]], [[7orf]], [[7s1n]], [[8bzp]], [[8elc]], [[8vnx]], [[8vo4]], [[8vs0]], [[8vtf]] – hMAPK10 catalytic domain + inhibitor<br />
**[[3ptg]], [[4h39]] - hMAPK10 catalytic domain + JIP1 peptide <br />
**[[3ptg]], [[4h39]] - hMAPK10 catalytic domain + JIP1 peptide <br />
**[[4h36]] – hMAPK10 catalytic domain + ATF2 peptide<br />
**[[4h36]] – hMAPK10 catalytic domain + ATF2 peptide<br />
Line 97: Line 113:
**[[4kke]], [[4kkg]] – hMAPK10 catalytic domain + AMPPNP<br />
**[[4kke]], [[4kkg]] – hMAPK10 catalytic domain + AMPPNP<br />
**[[6eq9]] – hMAPK10 catalytic domain + ACP<br />
**[[6eq9]] – hMAPK10 catalytic domain + ACP<br />
 +
**[[7yl1]] – hMAPK10 catalytic domain + purine derivative<br />
**[[3oxi]] - hMAPK10 + MAPK8 interacting protein + inhibitor<br />
**[[3oxi]] - hMAPK10 + MAPK8 interacting protein + inhibitor<br />
*MAPK11
*MAPK11
 +
**[[8ygw]] – hMAPK11 catalytic domain<br />
**[[3gp0]] – hMAPK11+inhibitor<br />
**[[3gp0]] – hMAPK11+inhibitor<br />
**[[3gc8]], [[3gc9]] – hMAPK11 (mutant)+inhibitor<br />
**[[3gc8]], [[3gc9]] – hMAPK11 (mutant)+inhibitor<br />
Line 111: Line 129:
*MAPK13
*MAPK13
-
**[[3coi]], [[4yno]], [[4myg]] – hMAPK13<br />
+
**[[3coi]], [[4myg]], [[4yno]], [[8x23]] – hMAPK13<br />
**[[4eyj]], [[4eym]], [[5ekn]], [[5eko]] - hMAPK13 +inhibitor<br />
**[[4eyj]], [[4eym]], [[5ekn]], [[5eko]] - hMAPK13 +inhibitor<br />
*MAPK14 or p38 alpha
*MAPK14 or p38 alpha
-
**[[3mgy]], [[3mh0]], [[3mh1]], [[3mh2]], [[3mh3]], [[3hvc]], [[3npq]], [[1wbo]], [[1r39]], [[2npq]], [[1wfc]], [[1cm8]], [[5etc]], [[5eti]], [[5uoj]] – hMAPK14<br />
+
**[[1cm8]], [[1r39]], [[1wbo]], [[1wfc]], [[2npq]], [[3hvc]], [[3mgy]], [[3mh0]], [[3mh1]], [[3mh2]], [[3mh3]], [[3npq]], [[5etc]], [[5eti]], [[5uoj]], [[9cj2]] – hMAPK14<br />
**[[2lgc]] – hMAPK14 – NMR<br />
**[[2lgc]] – hMAPK14 – NMR<br />
-
**[[3od6]], [[3ody]], [[3odz]], [[3oef]], [[3p4k]], [[2fsl]], [[2fsm]], [[2fso]], [[2fst]], [[1r3c]], [[4e5a]], [[4geo]] – hMAPK14 (mutant)<br />
+
**[[1r3c]], [[2fsl]], [[2fsm]], [[2fso]], [[2fst]], [[3od6]], [[3ody]], [[3odz]], [[3oef]], [[3p4k]], [[4e5a]], [[4geo]] – hMAPK14 (mutant)<br />
-
**[[3new]], [[3ocg]], [[3mvl]], [[3mvm]], [[3nnu]], [[3nnv]], [[3nnw]], [[3nnx]], [[3nww]], [[3mpt]], [[3lhj]], [[3huc]], [[3itz]], [[3l8x]], [[3kf7]], [[3fi4]], [[3fkl]], [[3fkn]], [[3fko]], [[3fl4]], [[3fln]], [[3flq]], [[3fls]], [[3flw]], [[3fly]], [[3flz]], [[3fmh]], [[3fmj]], [[3fmk]], [[3fml]], [[3flm]], [[3fln]], [[3fsf]], [[3fsk]], [[3kq7]], [[3iph]], [[3hv4]], [[3hv5]], [[3hv6]], [[3hv7]], [[3k3i]], [[3hec]], [[3heg]], [[3gi3]], [[3hp2]], [[3hp5]], [[3hrb]], [[3ha8]], [[3gfe]], [[3hl7]], [[3hll]], [[3gcu]], [[3fc1]], [[3dt1]], [[3e92]], [[3e93]], [[3d7z]], [[3d83]], [[3ctq]], [[2puu]], [[3bx5]], [[3c5u]], [[2zaz]], [[2zb0]], [[2zb1]], [[2qd9]], [[2ewa]], [[2gfs]], [[2baj]], [[2bak]], [[2bal]], [[2baq]], [[1zyj]], [[1wbn]], [[1wbs]], [[1wbt]], [[1wbv]], [[1wbw]], [[1zz2]], [[1zzl]], [[1yqj]], [[1w7h]], [[1w82]], [[1w83]], [[1w84]], [[1oz1]], [[1ouk]], [[1ouy]], [[1m7q]], [[1kv1]], [[1kv2]], [[1di9]], [[2rg5]], [[2rg6]], [[3bv3]], [[3bv2]], [[3fmm]], [[3fmn]], [[3lfa]], [[3mw1]], [[3pg3]], [[3roc]] ,[[2yis]], [[2yiw]], [[2yix]], [[3qud]], [[3que]], [[3rin]], [[3s3i]], [[3s4q]], [[3u8w]], [[3uvp]], [[3uvq]], [[3uvr]], [[3zs5]], [[3zsg]], [[3zsh]], [[3zsi]], [[3zya]], [[4a9y]], [[4aa0]], [[4aa4]], [[4aa5]], [[4aac]], [[4dli]], [[4dlj]], [[4e5b]], [[4eh2]], [[4eh3]], [[4eh4]], [[4eh5]], [[4eh6]], [[4eh7]], [[4eh8]], [[4eh9]], [[4ehv]], [[4ewq]], [[4f9w]], [[4f9y]], [[4fa2]], [[4kin]], [[4kip]], [[4kiq]], [[4l8m]], [[4r3c]], [[4zth]], [[5lar]], [[5ml5]], [[5omh]], [[5omg]], [[5tbe]], [[5tco]], [[6anl]], [[5xyy]], [[5xyx]], [[5wjj]], [[5n68]], [[5n67]], [[5n66]], [[5n65]], [[5n64]], [[5n63]], [[5mz3]], [[5mty]], [[5mtx]], [[5o8v]], [[5o8u]], [[6sfo]], [[6sfk]], [[6sfj]], [[6sfi]], [[6m9l]], [[6m95]], [[6hwv]], [[6hwu]], [[6hwt]], [[6ohd]], [[6qdz]], [[6qe1]], [[6sfi]], [[6sfj]], [[6sfk]], [[6sfo]], [[6so1]], [[6so2]], [[6so4]], [[6sod]], [[6soi]], [[6sot]], [[6sou]], [[6sov]], [[6sp9]], [[6spl]], [[6zwp]] - hMAPK14+inhibitor<br />
+
**[[1di9]], [[1kv1]], [[1kv2]], [[1m7q]], [[1ouk]], [[1ouy]], [[1oz1]], [[1zyj]], [[1w7h]], [[1w82]], [[1w83]], [[1w84]], [[1wbn]], [[1wbs]], [[1wbt]], [[1wbv]], [[1wbw]], [[1yqj]], [[1zz2]], [[1zzl]], [[2baj]], [[2bak]], [[2bal]], [[2baq]], [[2ewa]], [[2gfs]], [[2puu]], [[2qd9]], [[2rg5]], [[2rg6]], [[2yis]], [[2yiw]], [[2yix]], [[2zaz]], [[2zb0]], [[2zb1]], [[3bv2]], [[3bv3]], [[3bx5]], [[3c5u]], [[3ctq]], [[3d7z]], [[3d83]], [[3dt1]], [[3e92]], [[3e93]], [[3fc1]], [[3fi4]], [[3fkl]], [[3fkn]], [[3fko]], [[3fl4]], [[3flm]], [[3fln]], [[3fln]], [[3flq]], [[3fls]], [[3flw]], [[3fly]], [[3flz]], [[3fmh]], [[3fmj]], [[3fmk]], [[3fml]], [[3fmm]], [[3fmn]], [[3fsf]], [[3fsk]], [[3gcu]], [[3gfe]], [[3gi3]], [[3ha8]], [[3hec]], [[3heg]], [[3hl7]], [[3hll]], [[3hp2]], [[3hp5]], [[3hrb]], [[3huc]], [[3hv4]], [[3hv5]], [[3hv6]], [[3hv7]], [[3iph]], [[3itz]], [[3k3i]], [[3kf7]], [[3kq7]], [[3k3i]], [[3l8x]], [[3lfa]], [[3lhj]], [[3mpt]], [[3mw1]], [[3mvl]], [[3mvm]], [[3new]], [[3nnu]], [[3nnv]], [[3nnw]], [[3nnx]], [[3nww]], [[3ocg]], [[3pg3]], [[3qud]], [[3que]], [[3rin]], [[3roc]], [[3s3i]], [[3s4q]], [[3u8w]], [[3uvp]], [[3uvq]], [[3uvr]], [[3zs5]], [[3zsg]], [[3zsh]], [[3zsi]], [[3zya]], [[4a9y]], [[4aa0]], [[4aa4]], [[4aa5]], [[4aac]], [[4dli]], [[4dlj]], [[4e5b]], [[4eh2]], [[4eh3]], [[4eh4]], [[4eh5]], [[4eh6]], [[4eh7]], [[4eh8]], [[4eh9]], [[4ehv]], [[4ewq]], [[4f9w]], [[4f9y]], [[4fa2]], [[4kin]], [[4kip]], [[4kiq]], [[4l8m]], [[4r3c]], [[4zth]], [[5lar]], [[5ml5]], [[5mtx]], [[5mty]], [[5mz3]], [[5n63]], [[5n64]], [[5n65]], [[5n66]], [[5n67]], [[5n68]], [[5o8u]], [[5o8v]], [[5omg]], [[5omh]], [[5tbe]], [[5tco]], [[5wjj]], [[5xyx]], [[5xyy]], [[6anl]], [[6hwt]], [[6hwu]], [[6hwv]], [[6m95]], [[6m9l]], [[6ohd]], [[6qdz]], [[6qe1]], [[6sfi]], [[6sfj]], [[6sfk]], [[6sfo]], [[6so1]], [[6so2]], [[6so4]], [[6sod]], [[6soi]], [[6sot]], [[6sou]], [[6sov]], [[6sp9]], [[6spl]], [[6zwp]], [[7z6i]], [[8vxe]], [[8x38]], [[8yd9]], [[9cj4]], [[9d75]], [[9d7n]], [[9mhb]], [[9nyt]], [[9o4l]], [[9y8b]], [[9ylh]], [[9yty]] - hMAPK14+inhibitor<br />
 +
**[[1a9u]], [[1bl6]], [[1bl7]], [[1bmk]], [[1ian]], [[1ove]], [[2i0h]], [[3ds6]], [[3gc7]], [[3gcp]], [[3gcq]], [[3gcs]], [[3gcv]], [[3hub]], [[3hv3]], [[3iw5]], [[3iw6]], [[3iw7]], [[3iw8]], [[3k3j]], [[3l8s]], [[3lfb]], [[3lfc]], [[3lfd]], [[3lfe]], [[3lff]], [[3mpa]], [[3o8p]], [[3o8t]], [[3o8u]], [[3obg]], [[3obj]], [[3oc1]], [[5o8u]], [[5o8v]], [[7pvu]] - hMAPK14 (mutant)+inhibitor<br />
 +
**[[9cj1]], [[9cj3]], [[9cj5]] - hMAPK14+ drug<br />
**[[4e6a]], [[4e6c]], [[4e8a]] - hMAPK14+ lipid<br />
**[[4e6a]], [[4e6c]], [[4e8a]] - hMAPK14+ lipid<br />
-
**[[3o8t]], [[3mpa]], [[3obg]], [[3o8u]], [[3o8p]], [[3obj]], [[3oc1]], [[3hub]], [[3l8s]], [[3hv3]], [[3iw5]], [[3iw6]], [[3iw7]], [[3iw8]], [[3k3j]], [[3gc7]], [[3gcp]], [[3gcq]], [[3gcs]], [[3gcv]], [[3ds6]], [[2i0h]], [[1ove]], [[3lfb]], [[3lfc]], [[3lfd]], [[3lfe]], [[3lff]], [[1bl6]], [[1bl7]], [[1bmk]], [[1a9u]], [[1ian]] - hMAPK14 (mutant)+inhibitor<br />
+
**[[8a8m]] – hMAPK14 (mutant) + dual specificity MAP2K – Cryo EM<br />
**[[2y8o]] – hMAPK14 (mutant) + dual specificity MAP2K peptide<br />
**[[2y8o]] – hMAPK14 (mutant) + dual specificity MAP2K peptide<br />
**[[4ka3]], [[4loo]], [[4lop]], [[4loq]] – hMAPK14 + docking peptide<br />
**[[4ka3]], [[4loo]], [[4lop]], [[4loq]] – hMAPK14 + docking peptide<br />
 +
**[[8yp8]] – hMAPK14 + Tyr-protein phosphatase non-receptor peptide<br />
**[[5eta]], [[6zqs]] – hMAPK14 + peptide<br />
**[[5eta]], [[6zqs]] – hMAPK14 + peptide<br />
**[[3tg1]] – hMAPK14 + MAPK phosphatase 5<br />
**[[3tg1]] – hMAPK14 + MAPK phosphatase 5<br />
**[[5etf]] – hMAPK14 + MAPKK 6<br />
**[[5etf]] – hMAPK14 + MAPKK 6<br />
-
**[[2gtn]], [[2gtm]], [[3p5k]], [[3p78]], [[3p79]], [[3p7a]], [[3p7b]], [[3p7c]], [[6spl]], [[6sp9]], [[6sov]], [[6sou]], [[6sot]], [[6soi]], [[6sod]], [[6so4]], [[6so2]], [[6so1]], [[6y4t]], [[6y4u]], [[6y4v]], [[6y4w]], [[6y4x]], [[6y6v]], [[6yjc]], [[6yk7]], [[6zwr]] - mMAPK14+inhibitor<br />
+
**[[8acm]], [[8aco]] - mMAPK14<br />
-
**[[2ghm]], [[2ghl]], [[1ywr]], [[6y7w]], [[6y7x]], [[6y7y]], [[6y7z]], [[6y80]], [[6y81]], [[6y82]], [[6y85]], [[6y8h]], [[6ycu]], [[6ycw]], [[7bdo]], [[7bdq]], [[7be4]], [[7be5]] - mMAPK14 (mutant)+inhibitor<br />
+
**[[2gtm]], [[2gtn]], [[3p5k]], [[3p78]], [[3p79]], [[3p7a]], [[3p7b]], [[3p7c]], [[6sp9]], [[6spl]], [[6so1]], [[6so2]], [[6so4]], [[6sod]], [[6soi]], [[6sot]], [[6sou]], [[6sov]], [[6y4t]], [[6y4u]], [[6y4v]], [[6y4w]], [[6y4x]], [[6y6v]], [[6yjc]], [[6yk7]], [[6zwr]], [[7bdo]], [[7bdq]], [[7be4]], [[7be5]], [[8efj]], [[8vmh]], [[8vmm]], [[8vt6]], [[8vwm]] - mMAPK14+inhibitor<br />
 +
**[[1ywr]], [[2ghl]], [[2ghm]], [[6y7w]], [[6y7x]], [[6y7y]], [[6y7z]], [[6y80]], [[6y81]], [[6y82]], [[6y85]], [[6y8h]], [[6ycu]], [[6ycw]] - mMAPK14 (mutant)+inhibitor<br />
**[[3py3]] - mMAPK14 phosphorylated<br />
**[[3py3]] - mMAPK14 phosphorylated<br />
**[[1yw2]], [[5uoj]] - mMAPK14 (mutant)<br />
**[[1yw2]], [[5uoj]] - mMAPK14 (mutant)<br />
**[[1lew]] - mMAPK14+MEF2A<br />
**[[1lew]] - mMAPK14+MEF2A<br />
**[[1lez]] - mMAPK14+MKK3B<br />
**[[1lez]] - mMAPK14+MKK3B<br />
 +
**[[8ype]], [[8ypf]] - mMAPK14+ ATF-2<br />
**[[5nzz]] – mMAPK14 + TGF <br />
**[[5nzz]] – mMAPK14 + TGF <br />
**[[5o90]] – mMAPK14 (mutant) + TGF peptide<br />
**[[5o90]] – mMAPK14 (mutant) + TGF peptide<br />
 +
**[[7z9t]] – mMAPK14 (mutant) + ATPgS + inhibitor<br />
**[[3oht]] – MAPK14 – ''Salmo salar'' <br />
**[[3oht]] – MAPK14 – ''Salmo salar'' <br />
*MAPK Fus3
*MAPK Fus3
-
**[[2f9g]], [[2b9f]] – yMAPK Fus3 – yeast<br />
+
**[[2f9f]], [[2b9g]] – yMAPK Fus3 – yeast<br />
**[[2fa2]] – yMAPK Fus3 (mutant)<br />
**[[2fa2]] – yMAPK Fus3 (mutant)<br />
**[[2f49]] - yMAPK Fus3 +STE5 peptide<br />
**[[2f49]] - yMAPK Fus3 +STE5 peptide<br />
**[[2b9h]], [[2b9i]] - yMAPK Fus3 (mutant)+MSG5 peptide<br />
**[[2b9h]], [[2b9i]] - yMAPK Fus3 (mutant)+MSG5 peptide<br />
**[[2b9j]] - yMAPK Fus3 (mutant)+FAR1 peptide<br />
**[[2b9j]] - yMAPK Fus3 (mutant)+FAR1 peptide<br />
- 
*MAPK
*MAPK
- 
**[[3rp9]] – TgMAPK – ''Toxoplasma gondii''<br />
**[[3rp9]] – TgMAPK – ''Toxoplasma gondii''<br />
**[[6v6a]] – TgMAPK + AC9 peptide<br />
**[[6v6a]] – TgMAPK + AC9 peptide<br />
**[[3uib]] – MAPK + inhibitor – ''Leishmania major''<br />
**[[3uib]] – MAPK + inhibitor – ''Leishmania major''<br />
 +
*MAPK MPS1
 +
**[[8ztc]] – PoMAPK – ''Pyricularia oryzae''<br />
 +
**[[8h59]] – PoMAPK + inhibitor <br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Mitogen-activated protein kinase

Updated on 29-December-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Mitogen-activated_protein_kinase_3D_structures"
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