GABAA receptor
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='5o8f' size='340' side='right' caption='Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with pregnanolone (based on 5o8f) scene='89/896619/Cv/3'>...) |
|||
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
<StructureSection load='5o8f' size='340' side='right' caption='Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with pregnanolone (based on [[5o8f]]) scene='89/896619/Cv/3'> | <StructureSection load='5o8f' size='340' side='right' caption='Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with pregnanolone (based on [[5o8f]]) scene='89/896619/Cv/3'> | ||
| - | + | '''GABAA receptors''', which are considered ligand-gated ion channels as the binding of GABA results in the opening of ion channels leading to the inhibition of a neuronal signal. Excitatory neurosteroids have excitatory effects on neurotransmission. They act as potent negative allosteric modulators of the GABAA receptor. Major examples include the pregnanes pregnenolone sulfate (PS), epipregnanolone, and isopregnanolone (sepranolone). | |
| - | + | *<scene name='89/896619/Cv/5'>Pregnenolone alone</scene>. | |
| + | *<scene name='89/896619/Cv/4'>Pregnanolone binds beta3-alpha5 GABAA receptor</scene> ([[5o8f]]). | ||
| + | *<scene name='89/896619/Cv/6'>Pregnanolone binding site is situated between 2 monomers</scene>. | ||
| - | == | + | See also: |
| + | *[[GABA receptor]] | ||
| + | *[[Steroids]] | ||
| + | *[[Neurosteroids]] | ||
| + | *[[Inhibitory neurosteroids]] | ||
| + | *[[Excitatory neurosteroids]] | ||
| + | </StructureSection> | ||
| + | ==GABAA receptor 3D structures== | ||
| - | + | See [[GABA receptor 3D structures]] | |
| - | == Relevance == | ||
| - | |||
| - | == Structural highlights == | ||
| - | |||
| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
| - | |||
| - | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
GABAA receptor 3D structures
See GABA receptor 3D structures
