2m0q

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==Solution NMR analysis of intact KCNE2 in detergent micelles demonstrate a straight transmembrane helix==
==Solution NMR analysis of intact KCNE2 in detergent micelles demonstrate a straight transmembrane helix==
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<StructureSection load='2m0q' size='340' side='right'caption='[[2m0q]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='2m0q' size='340' side='right'caption='[[2m0q]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2m0q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M0Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2m0q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M0Q FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCNE2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m0q OCA], [https://pdbe.org/2m0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m0q RCSB], [https://www.ebi.ac.uk/pdbsum/2m0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m0q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m0q OCA], [https://pdbe.org/2m0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m0q RCSB], [https://www.ebi.ac.uk/pdbsum/2m0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m0q ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/KCNE2_HUMAN KCNE2_HUMAN]] Familial atrial fibrillation;Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/KCNE2_HUMAN KCNE2_HUMAN] Familial atrial fibrillation;Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/KCNE2_HUMAN KCNE2_HUMAN]] Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current.
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[https://www.uniprot.org/uniprot/KCNE2_HUMAN KCNE2_HUMAN] Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, L]]
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[[Category: Chen L]]
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[[Category: Lai, C]]
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[[Category: Lai C]]
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[[Category: Li, P]]
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[[Category: Li P]]
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[[Category: Tian, C]]
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[[Category: Tian C]]
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[[Category: Wu, F]]
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[[Category: Wu F]]
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[[Category: Zhang, L]]
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[[Category: Zhang L]]
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[[Category: Detergent micelle]]
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[[Category: Membrane protein]]
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[[Category: Transmembrane helix]]
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Current revision

Solution NMR analysis of intact KCNE2 in detergent micelles demonstrate a straight transmembrane helix

PDB ID 2m0q

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