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6yxh

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Current revision (13:37, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6yxh' size='340' side='right'caption='[[6yxh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='6yxh' size='340' side='right'caption='[[6yxh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6yxh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YXH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6yxh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YXH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6g7o|6g7o]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACER3, APHC, PHCA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yxh OCA], [https://pdbe.org/6yxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yxh RCSB], [https://www.ebi.ac.uk/pdbsum/6yxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yxh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yxh OCA], [https://pdbe.org/6yxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yxh RCSB], [https://www.ebi.ac.uk/pdbsum/6yxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yxh ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/ACER3_HUMAN ACER3_HUMAN]] Alkaline ceramidase 3 deficiency.
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[https://www.uniprot.org/uniprot/ACER3_HUMAN ACER3_HUMAN] Alkaline ceramidase 3 deficiency.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ACER3_HUMAN ACER3_HUMAN]] Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.
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[https://www.uniprot.org/uniprot/ACER3_HUMAN ACER3_HUMAN] Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6yxh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6yxh" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ceramidase 3D PDB structures|Ceramidase 3D PDB structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Basu, S]]
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[[Category: Basu S]]
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[[Category: Dupeux, F]]
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[[Category: Dupeux F]]
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[[Category: Granier, S]]
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[[Category: Granier S]]
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[[Category: Healey, R D]]
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[[Category: Healey RD]]
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[[Category: Humm, A S]]
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[[Category: Humm AS]]
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[[Category: Leyrat, C]]
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[[Category: Leyrat C]]
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[[Category: Marquez, J A]]
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[[Category: Marquez JA]]
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[[Category: Pica, A]]
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[[Category: Pica A]]
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[[Category: Acer3]]
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[[Category: Alkaline ceramidase]]
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[[Category: Crystaldirect]]
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[[Category: Htx facility]]
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[[Category: In meso]]
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[[Category: Lcp crystallisation]]
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[[Category: Membrane protein]]
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[[Category: Serial synchrotron crystallography]]
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[[Category: Ssx]]
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Current revision

Cryogenic human alkaline ceramidase 3 (ACER3) at 2.6 A resolution determined by Serial Crystallography (SSX) using CrystalDirect

PDB ID 6yxh

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