7l6d

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Current revision (15:38, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7l6d' size='340' side='right'caption='[[7l6d]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='7l6d' size='340' side='right'caption='[[7l6d]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7l6d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L6D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7l6d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L6D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMF:BROMOSPORINE'>BMF</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD2, KIAA9001, RING3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMF:BROMOSPORINE'>BMF</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l6d OCA], [https://pdbe.org/7l6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l6d RCSB], [https://www.ebi.ac.uk/pdbsum/7l6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l6d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l6d OCA], [https://pdbe.org/7l6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l6d RCSB], [https://www.ebi.ac.uk/pdbsum/7l6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l6d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
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[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7l6d" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7l6d" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bikowitz, M J]]
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[[Category: Bikowitz MJ]]
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[[Category: Chan, A]]
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[[Category: Chan A]]
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[[Category: Karim, M R]]
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[[Category: Karim MR]]
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[[Category: Schonbrunn, E]]
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[[Category: Schonbrunn E]]
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[[Category: Bet]]
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[[Category: Dual brd-kinase inhibitor]]
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[[Category: Erk5]]
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[[Category: Gene regulation]]
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Current revision

Crystal structure of the second bromodomain (BD2) of human BRD2 bound to bromosporine

PDB ID 7l6d

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