2y7q

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Current revision (08:09, 23 August 2023) (edit) (undo)
 
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<StructureSection load='2y7q' size='340' side='right'caption='[[2y7q]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
<StructureSection load='2y7q' size='340' side='right'caption='[[2y7q]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y7q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y7Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2y7q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y7Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fp5|1fp5]], [[1f6a|1f6a]], [[1j87|1j87]], [[1o0v|1o0v]], [[1j88|1j88]], [[1j86|1j86]], [[1j89|1j89]], [[1g84|1g84]], [[1ige|1ige]], [[1rpq|1rpq]], [[1f2q|1f2q]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7q OCA], [https://pdbe.org/2y7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y7q RCSB], [https://www.ebi.ac.uk/pdbsum/2y7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7q OCA], [https://pdbe.org/2y7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y7q RCSB], [https://www.ebi.ac.uk/pdbsum/2y7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FCERA_HUMAN FCERA_HUMAN]] Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
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[https://www.uniprot.org/uniprot/FCERA_HUMAN FCERA_HUMAN] Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Beavil, A J]]
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[[Category: Beavil AJ]]
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[[Category: Davies, A M]]
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[[Category: Davies AM]]
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[[Category: Holdom, M D]]
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[[Category: Holdom MD]]
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[[Category: Nettleship, J E]]
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[[Category: Nettleship JE]]
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[[Category: Owens, R J]]
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[[Category: Owens RJ]]
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[[Category: Sutton, B J]]
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[[Category: Sutton BJ]]
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[[Category: Allergy]]
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[[Category: Antibody]]
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[[Category: High-affinity receptor]]
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[[Category: Ige-binding protein]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin c region]]
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Current revision

THE HIGH-AFFINITY COMPLEX BETWEEN IGE AND ITS RECEPTOR FC EPSILON RI

PDB ID 2y7q

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