NK cell receptor

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Current revision (07:43, 20 July 2023) (edit) (undo)
 
Line 23: Line 23:
*NKG2D
*NKG2D
-
**[[1hq8]] – mNKG2D extracellular domain – mouse<br />
 
**[[1mpu]] – hNKG2D extracellular domain – human<br />
**[[1mpu]] – hNKG2D extracellular domain – human<br />
-
**[[1hyr]] – hNKG2D extracellular domain + class I MHC-like ligand MICA <br />
+
**[[1hyr]], [[7fi5]], [[7fi6]], [[7fi7]], [[7fi8]], [[7fi9]] – hNKG2D extracellular domain + class I MHC-like ligand MICA <br />
**[[1kcg]] – hNKG2D extracellular domain + class I MHC-like ligand ULBP3<br />
**[[1kcg]] – hNKG2D extracellular domain + class I MHC-like ligand ULBP3<br />
**[[4s0u]] – hNKG2D extracellular domain + retinoic acid early transcript 1L protein <br />
**[[4s0u]] – hNKG2D extracellular domain + retinoic acid early transcript 1L protein <br />
Line 32: Line 31:
**[[3bdw]] – hNKG2D extracellular domain + CD94<br />
**[[3bdw]] – hNKG2D extracellular domain + CD94<br />
**[[3bdw]], [[3cii]] – hNKG2D extracellular domain + CD94 + MHC class I antigen E + β-2-microglobulin + HLA G antigen<br />
**[[3bdw]], [[3cii]] – hNKG2D extracellular domain + CD94 + MHC class I antigen E + β-2-microglobulin + HLA G antigen<br />
 +
**[[8ea5]], [[8ea6]], [[8ea7]], [[8ea8]], [[8ea9]], [[8eaa]], [[8eab]] – hNKG2D extracellular domain + inhibitor<br />
 +
**[[1hq8]] – mNKG2D extracellular domain – mouse<br />
*NKp
*NKp
Line 57: Line 58:
**[[3wyr]] – hKIR2dl4 extracellular domain <br />
**[[3wyr]] – hKIR2dl4 extracellular domain <br />
**[[3h8n]] – hKIR2ds4 extracellular domain <br />
**[[3h8n]] – hKIR2ds4 extracellular domain <br />
-
**[[3wuw]], [[5t70]], [[5t6z]], [[5b39]], [[5b38]], [[3vh8]], [[6v3j]], [[7k80]] – hKIR3dl1
+
**[[3wuw]], [[5t70]], [[5t6z]], [[5b39]], [[5b38]], [[3vh8]], [[6v3j]], [[7duu]], [[7k80]] – hKIR3dl1 extracellular domain + MHC class I antigen B + β-2-microglobulin + IG κ chain C region<br />
-
extracellular domain + MHC class I antigen B + β-2-microglobulin + IG κ chain C region<br />
+
**[[6pag]] – hKIR3dl3 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide<br />
**[[6pag]] – hKIR3dl3 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide<br />
**[[6pa1]] – hKIR2dl2 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide<br />
**[[6pa1]] – hKIR2dl2 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide<br />

Current revision

Human NK cell receptor NKG2D (grey and green) complex with class I MHC-like ligand ULBP3 (pink) and glutathione (PDB entry 1kcg)

Drag the structure with the mouse to rotate

3D structures of NK cell receptor

Updated on 20-July-2023

References

  1. Lanier LL. NK cell receptors. Annu Rev Immunol. 1998;16:359-93. PMID:9597134 doi:http://dx.doi.org/10.1146/annurev.immunol.16.1.359
  2. Mathew SO, Rao KK, Kim JR, Bambard ND, Mathew PA. Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur J Immunol. 2009 Jun;39(6):1632-41. doi: 10.1002/eji.200838733. PMID:19499526 doi:http://dx.doi.org/10.1002/eji.200838733
  3. Kane KP, Lavender KJ, Ma BJ. Ly-49 receptors and their functions. Crit Rev Immunol. 2004;24(5):321-48. PMID:15663362
  4. Norman PJ, Carrington CV, Byng M, Maxwell LD, Curran MD, Stephens HA, Chandanayingyong D, Verity DH, Hameed K, Ramdath DD, Vaughan RW. Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. Genes Immun. 2002 Apr;3(2):86-95. PMID:11960306 doi:http://dx.doi.org/10.1038/sj.gene.6363836
  5. Raulet DH. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol. 2003 Oct;3(10):781-90. PMID:14523385 doi:http://dx.doi.org/10.1038/nri1199

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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