7qb5
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Coxsackievirus A24v (CVA24v) in complex with a dimeric C2-C9-linked sialic acid inhibitor== | |
| + | <StructureSection load='7qb5' size='340' side='right'caption='[[7qb5]], [[Resolution|resolution]] 1.73Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7qb5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A24 Coxsackievirus A24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QB5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.728Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qb5 OCA], [https://pdbe.org/7qb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qb5 RCSB], [https://www.ebi.ac.uk/pdbsum/7qb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qb5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/V9VEF3_9ENTO V9VEF3_9ENTO] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Coxsackievirus A24 variant (CVA24v) is responsible for several outbreaks and two pandemics of the highly contagious eye infection acute hemorrhagic conjunctivitis (AHC). Currently, neither prevention (vaccines) nor treatments (antivirals) are available for combating this disease. CVA24v attaches to cells by binding Neu5Ac-containing glycans on the surface of cells which facilitates entry. Previously, we have demonstrated that pentavalent Neu5Ac conjugates attenuate CVA24v infection of human corneal epithelial (HCE) cells. In this study, we report on the structure-based design of three classes of divalent Neu5Ac conjugates, with varying spacer lengths, and their effect on CVA24v transduction in HCE cells. In relative terms, the most efficient class of divalent Neu5Ac conjugates are more efficient than the pentavalent Neu5Ac conjugates previously reported. | ||
| - | + | Exploring divalent conjugates of 5-N-acetyl-neuraminic acid as inhibitors of coxsackievirus A24 variant (CVA24v) transduction.,Johansson E, Caraballo R, Zocher G, Mistry N, Arnberg N, Stehle T, Elofsson M RSC Adv. 2022 Jan 14;12(4):2319-2331. doi: 10.1039/d1ra08968d. eCollection 2022, Jan 12. PMID:35425270<ref>PMID:35425270</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 7qb5" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Coxsackievirus A24]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Stehle T]] | ||
| + | [[Category: Zocher G]] | ||
Current revision
Coxsackievirus A24v (CVA24v) in complex with a dimeric C2-C9-linked sialic acid inhibitor
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