| Structural highlights
Function
COR1C_HUMAN Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity).[UniProtKB:Q9WUM4][1] [2] [3] [4] Involved in myogenic differentiation.[5]
References
- ↑ Williamson RC, Cowell CA, Hammond CL, Bergen DJ, Roper JA, Feng Y, Rendall TC, Race PR, Bass MD. Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. J Cell Sci. 2014 Oct 1;127(Pt 19):4292-307. PMID:25074804 doi:10.1242/jcs.154864
- ↑ Williamson RC, Cowell CAM, Reville T, Roper JA, Rendall TCS, Bass MD. Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein Trafficking. J Biol Chem. 2015 Jun 19;290(25):15437-15449. PMID:25925950 doi:10.1074/jbc.M115.640367
- ↑ Hoyer MJ, Chitwood PJ, Ebmeier CC, Striepen JF, Qi RZ, Old WM, Voeltz GK. A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission. Cell. 2018 Sep 20;175(1):254-265.e14. PMID:30220460 doi:10.1016/j.cell.2018.08.030
- ↑ Galloni C, Carra D, Abella JVG, Kjær S, Singaravelu P, Barry DJ, Kogata N, Guérin C, Blanchoin L, Way M. MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes. J Cell Biol. 2021 Aug 2;220(8):e202102043. PMID:34106209 doi:10.1083/jcb.202102043
- ↑ Xavier CP, Rastetter RH, Stumpf M, Rosentreter A, Müller R, Reimann J, Cornfine S, Linder S, van Vliet V, Hofmann A, Morgan RO, Fernandez MP, Schröder R, Noegel AA, Clemen CS. Structural and functional diversity of novel coronin 1C (CRN2) isoforms in muscle. J Mol Biol. 2009 Oct 23;393(2):287-99. PMID:19651142 doi:10.1016/j.jmb.2009.07.079
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