7vzo
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7vzo is ON HOLD Authors: He, X., Jin, T. Description: crystal structure of Domain 5-6 of filamin C from Scylla paramamosain [[Category: Unreleased ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==crystal structure of Domain 5-6 of filamin C from Scylla paramamosain== | |
| + | <StructureSection load='7vzo' size='340' side='right'caption='[[7vzo]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7vzo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Scylla_paramamosain Scylla paramamosain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VZO FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vzo OCA], [https://pdbe.org/7vzo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vzo RCSB], [https://www.ebi.ac.uk/pdbsum/7vzo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vzo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A5J6X3F8_SCYPA A0A5J6X3F8_SCYPA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Filamin C (FLN c) is a novel allergen in shellfish. In this study, FLN c from Scylla paramamosain was divided into three regions for recombinant expression based on the number of domains and amino acids. Using dot blot and basophil activation tests, the allergic predominant region of FLN c was determined to be 336-531 amino acid positions (named FLN c-M). It was confirmed that by X-ray diffraction, the crystal structure of FLN c-M with immunoglobulin-like folding at a resolution of 1.7 A was obtained. The monomer was a barrel structure composed of 16 beta-strands and 2 alpha-helices. Three conformational epitopes were predicted, six linear epitopes were verified by serological test, and they were positioned on the crystal structure of FLN c-M. For the first time, the crystal structure of the allergic predominant region of FLN c was determined, and it provided an accurate template for the localization of IgE epitopes. | ||
| - | + | Crystal Structure Analysis and IgE Epitope Mapping of Allergic Predominant Region in Scylla paramamosain Filamin C, Scy p 9.,He XR, Yang Y, Kang S, Chen YX, Zheng PY, Chen GX, Chen XM, Cao MJ, Jin T, Liu GM J Agric Food Chem. 2022 Feb 2;70(4):1282-1292. doi: 10.1021/acs.jafc.1c07922., Epub 2022 Jan 18. PMID:35040643<ref>PMID:35040643</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 7vzo" style="background-color:#fffaf0;"></div> |
| - | [[Category: He | + | |
| + | ==See Also== | ||
| + | *[[Filamin 3D structures|Filamin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Scylla paramamosain]] | ||
| + | [[Category: He X]] | ||
| + | [[Category: Jin T]] | ||
Current revision
crystal structure of Domain 5-6 of filamin C from Scylla paramamosain
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