7rsj
From Proteopedia
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==Structure of the VPS34 kinase domain with compound 14== | ==Structure of the VPS34 kinase domain with compound 14== | ||
| - | <StructureSection load='7rsj' size='340' side='right'caption='[[7rsj]]' scene=''> | + | <StructureSection load='7rsj' size='340' side='right'caption='[[7rsj]], [[Resolution|resolution]] 1.88Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RSJ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7rsj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RSJ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rsj OCA], [https://pdbe.org/7rsj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rsj RCSB], [https://www.ebi.ac.uk/pdbsum/7rsj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rsj ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.881Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7IH:N-{4-[(7R,8R)-4-oxo-7-(propan-2-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl]pyridin-2-yl}cyclopropanecarboxamide'>7IH</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rsj OCA], [https://pdbe.org/7rsj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rsj RCSB], [https://www.ebi.ac.uk/pdbsum/7rsj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rsj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chan GKY]] | [[Category: Chan GKY]] | ||
Current revision
Structure of the VPS34 kinase domain with compound 14
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Categories: Homo sapiens | Large Structures | Chan GKY | Chen H | Chen Y | Dimitrova YN | Hu DX | Huang H | Lee JY | Lim J | McNamara E | Moffat JG | Murthy A | Pang J | Patel S | Prangley MS | Salphati L | Schutt LK | Siu M | Sneeringer CJ | Staben S | Wallweber HA | Wang S | Wang Y | Wu C | Zhao W
