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2hug

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==3D Solution Structure of the Chromo-2 Domain of cpSRP43 complexed with cpSRP54 peptide==
==3D Solution Structure of the Chromo-2 Domain of cpSRP43 complexed with cpSRP54 peptide==
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<StructureSection load='2hug' size='340' side='right'caption='[[2hug]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2hug' size='340' side='right'caption='[[2hug]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2hug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HUG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2hug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HUG FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAO ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hug OCA], [https://pdbe.org/2hug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hug RCSB], [https://www.ebi.ac.uk/pdbsum/2hug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hug ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hug OCA], [https://pdbe.org/2hug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hug RCSB], [https://www.ebi.ac.uk/pdbsum/2hug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hug ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SR43C_ARATH SR43C_ARATH]] Component of the chloroplast signal recognition particle pathway. Required for post-translational targeting of proteins into the tylakoid membrane but seems to be dispensable for co-translational targeting with a translating ribosome present. May be able to function independently of cpFTSY and FFC/cpSRP54 in targeting LHCPs to the thylakoids. Acts as a highly specific chaperone for LHCPs, preventing aggregation and being able to dissolve aggregates.<ref>PMID:9878634</ref> <ref>PMID:10480939</ref> <ref>PMID:15292240</ref> <ref>PMID:17513500</ref> <ref>PMID:20498370</ref> [[https://www.uniprot.org/uniprot/SR54C_ARATH SR54C_ARATH]] Involved in cotranslational and post-translational sorting of thylakoid proteins. Binds GTP specifically. Activates the GTPase activity of CPFTSY when bound together. Required for light-harvesting chlorophyll a/b-binding protein (LHCP) integration into thylakoids.<ref>PMID:10480939</ref> <ref>PMID:11356852</ref> <ref>PMID:17475780</ref> <ref>PMID:18633119</ref>
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[https://www.uniprot.org/uniprot/SR43C_ARATH SR43C_ARATH] Component of the chloroplast signal recognition particle pathway. Required for post-translational targeting of proteins into the tylakoid membrane but seems to be dispensable for co-translational targeting with a translating ribosome present. May be able to function independently of cpFTSY and FFC/cpSRP54 in targeting LHCPs to the thylakoids. Acts as a highly specific chaperone for LHCPs, preventing aggregation and being able to dissolve aggregates.<ref>PMID:9878634</ref> <ref>PMID:10480939</ref> <ref>PMID:15292240</ref> <ref>PMID:17513500</ref> <ref>PMID:20498370</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Signal recognition particle protein|Signal recognition particle protein]]
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*[[Signal recognition particle 3D structures|Signal recognition particle 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arath]]
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[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Henry, R]]
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[[Category: Henry R]]
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[[Category: Kathir, K M]]
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[[Category: Kathir KM]]
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[[Category: Thallapuranam, S K.K]]
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[[Category: Thallapuranam SKK]]
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[[Category: Vaithiyalingam, S]]
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[[Category: Vaithiyalingam S]]
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[[Category: Chromo-2 domain]]
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[[Category: Cpsrp43]]
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[[Category: Cpsrp54]]
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[[Category: Lhcp]]
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[[Category: Plant protein]]
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[[Category: Protein translocation]]
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[[Category: Thylakoid]]
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Current revision

3D Solution Structure of the Chromo-2 Domain of cpSRP43 complexed with cpSRP54 peptide

PDB ID 2hug

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