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2yqk

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Current revision (19:16, 29 May 2024) (edit) (undo)
 
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==Solution structure of the SANT domain in Arginine-glutamic acid dipeptide (RE) repeats==
==Solution structure of the SANT domain in Arginine-glutamic acid dipeptide (RE) repeats==
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<StructureSection load='2yqk' size='340' side='right'caption='[[2yqk]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2yqk' size='340' side='right'caption='[[2yqk]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YQK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YQK FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RERE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yqk OCA], [https://pdbe.org/2yqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yqk RCSB], [https://www.ebi.ac.uk/pdbsum/2yqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yqk ProSAT], [https://www.topsan.org/Proteins/RSGI/2yqk TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yqk OCA], [https://pdbe.org/2yqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yqk RCSB], [https://www.ebi.ac.uk/pdbsum/2yqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yqk ProSAT], [https://www.topsan.org/Proteins/RSGI/2yqk TOPSAN]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/RERE_HUMAN RERE_HUMAN]] Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line NGP. Translocation t(1;15)(p36.2;q24).
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[https://www.uniprot.org/uniprot/RERE_HUMAN RERE_HUMAN] Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line NGP. Translocation t(1;15)(p36.2;q24).
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RERE_HUMAN RERE_HUMAN]] Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.<ref>PMID:11331249</ref>
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[https://www.uniprot.org/uniprot/RERE_HUMAN RERE_HUMAN] Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.<ref>PMID:11331249</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: He, F]]
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[[Category: He F]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kadirvel, S]]
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[[Category: Kadirvel S]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y]]
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[[Category: Muto Y]]
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[[Category: Structural genomic]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M]]
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[[Category: Tarada T]]
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[[Category: Tarada, T]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Sant domain]]
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[[Category: Transcription-apoptosis complex]]
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Current revision

Solution structure of the SANT domain in Arginine-glutamic acid dipeptide (RE) repeats

PDB ID 2yqk

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