2yrq
From Proteopedia
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==Solution structure of the tandem HMG box domain from Human High mobility group protein B1== | ==Solution structure of the tandem HMG box domain from Human High mobility group protein B1== | ||
| - | <StructureSection load='2yrq' size='340' side='right'caption='[[2yrq | + | <StructureSection load='2yrq' size='340' side='right'caption='[[2yrq]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yrq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2yrq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YRQ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yrq OCA], [https://pdbe.org/2yrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yrq RCSB], [https://www.ebi.ac.uk/pdbsum/2yrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yrq ProSAT], [https://www.topsan.org/Proteins/RSGI/2yrq TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yrq OCA], [https://pdbe.org/2yrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yrq RCSB], [https://www.ebi.ac.uk/pdbsum/2yrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yrq ProSAT], [https://www.topsan.org/Proteins/RSGI/2yrq TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/HMGB1_HUMAN HMGB1_HUMAN] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Harada | + | [[Category: Harada T]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Koshiba | + | [[Category: Koshiba S]] |
| - | + | [[Category: Tomizawa T]] | |
| - | [[Category: Tomizawa | + | [[Category: Watanabe S]] |
| - | [[Category: Watanabe | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution structure of the tandem HMG box domain from Human High mobility group protein B1
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