This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Nonstructural protein 3D structures
From Proteopedia
(Difference between revisions)
| (6 intermediate revisions not shown.) | |||
| Line 31: | Line 31: | ||
**[[1nhu]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 – Hepatitis C virus<br /> | **[[1nhu]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 – Hepatitis C virus<br /> | ||
**[[1r7c]], [[1r7d]], [[1r7e]], [[1r7f]], [[1r7g]] - HvNS5A membrane-anchor domain - NMR<br /> | **[[1r7c]], [[1r7d]], [[1r7e]], [[1r7f]], [[1r7g]] - HvNS5A membrane-anchor domain - NMR<br /> | ||
| - | **[[2gdt]], [[2hsx]] – SvNS1 (mutant) | + | **[[8a55]] – SvNS1 N-terminal 11-125 – Sars coronavirus <br /> |
| + | **[[7eq4]] – SvNS1 N-terminal 11-125 (mutant) <br /> | ||
| + | **[[2gdt]], [[2hsx]] – SvNS1 N-terminal (mutant) – NMR<br /> | ||
| + | **[[7ci3]], [[7lhq]] – SvNS7A<br /> | ||
| + | **[[7bwq]] – SvNS9<br /> | ||
**[[2l8k]] – NS7 residues 1454-1575 – Arterivirus - NMR<br /> | **[[2l8k]] – NS7 residues 1454-1575 – Arterivirus - NMR<br /> | ||
**[[3mtv]] – PrrsvNS1 residues 181-383 – PRRS virus <br /> | **[[3mtv]] – PrrsvNS1 residues 181-383 – PRRS virus <br /> | ||
| Line 38: | Line 42: | ||
**[[4r05]] – DvNS5 residues 2491-2752 <br /> | **[[4r05]] – DvNS5 residues 2491-2752 <br /> | ||
**[[4x2z]] – NS3 residues 1174-1483 – Avian infectious bronchitis virus<br /> | **[[4x2z]] – NS3 residues 1174-1483 – Avian infectious bronchitis virus<br /> | ||
| - | **[[5rhl]], [[6mh3]] – ZvNS3 helicase domain 1681-2115 – Zika virus<br /> | ||
**[[4cbg]], [[4cbh]], [[4cbl]], [[4cbm]] – NS3 – Swine fever virus<br /> | **[[4cbg]], [[4cbh]], [[4cbl]], [[4cbm]] – NS3 – Swine fever virus<br /> | ||
| - | **[[2hwk]] – | + | **[[2hwk]] – VeevNS2 – Venzuelan equine encephalitis virus<br /> |
| + | **[[8duf]] – VeevNS2 (mutant)<br /> | ||
**[[6lp9]] – fipvNSP1 – Feline infectious peritonitis virus<br /> | **[[6lp9]] – fipvNSP1 – Feline infectious peritonitis virus<br /> | ||
**[[3ub0]] – fipvNSP6 + NSP7 <br /> | **[[3ub0]] – fipvNSP6 + NSP7 <br /> | ||
| Line 47: | Line 51: | ||
**[[6n9y]] – NS1 – Bluetongue virus<br /> | **[[6n9y]] – NS1 – Bluetongue virus<br /> | ||
**[[6vdo]] – HcvNS3 (mutant) – Hepacivirus C<br /> | **[[6vdo]] – HcvNS3 (mutant) – Hepacivirus C<br /> | ||
| - | **[[ | + | **[[7oj4]], [[7jno]] – NS3 helicase domain – Tick-borne encephalitis virus<br /> |
| + | **[[7dop]] – CvNS1 – Chicungunya virus - Cryo EM<br /> | ||
| + | |||
| + | *For Zika virus nonstructural proteins NS2B and NS3 see [[Virus protease]] | ||
*Nonstructural protein complex | *Nonstructural protein complex | ||
| Line 59: | Line 66: | ||
**[[2hye]] – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5<br /> | **[[2hye]] – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5<br /> | ||
**[[2b5l]] - SvNSV + DNA damage-binding protein<br /> | **[[2b5l]] - SvNSV + DNA damage-binding protein<br /> | ||
| + | **[[7t70]], [[7t8m]], [[7t8r]], [[7t9y]], [[7ta4]], [[7ta7]], [[7tb2]], [[7tbt]], [[7tc4]] - SvNSV + 3C-like proteinase<br /> | ||
**[[1nhv]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 + inhibitor<br /> | **[[1nhv]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 + inhibitor<br /> | ||
**[[1dxp]], [[1dy8]], [[1dy9]], [[1w3c]] – HvNS4A + HvHelicase NS3<br /> | **[[1dxp]], [[1dy8]], [[1dy9]], [[1w3c]] – HvNS4A + HvHelicase NS3<br /> | ||
| Line 69: | Line 77: | ||
**[[4r8r]] – DvNS5 residues 2491-2752 + adenosyl-Met<br /> | **[[4r8r]] – DvNS5 residues 2491-2752 + adenosyl-Met<br /> | ||
**[[4r8s]] – DvNS5 residues 2491-2752 + sinefungin<br /> | **[[4r8s]] – DvNS5 residues 2491-2752 + sinefungin<br /> | ||
| - | **[[6ux2]] – ZvNS5 residues 2789-3419 + P113 | + | **[[6ux2]] – ZvNS5 residues 2789-3419 + P113 - Zika virus<br /> |
| - | + | ||
| - | + | ||
| - | + | ||
**[[6wcz]] – ZvNS5 + hSTAT2<br /> | **[[6wcz]] – ZvNS5 + hSTAT2<br /> | ||
**[[6i7p]] – ZvNS5 + SAH<br /> | **[[6i7p]] – ZvNS5 + SAH<br /> | ||
| + | **[[7x01]] – CvNS1 + inhibitor – Cryo EM<br /> | ||
| + | **[[6jim]] – CvNS2 + RNA <br /> | ||
| + | **[[7fgg]], [[7fgh]], [[7fgi]] – CvNS1 + nucleotide – Cryo EM<br /> | ||
**[[6jim]] – NS2 + RNA – Chicungunya virus<br /> | **[[6jim]] – NS2 + RNA – Chicungunya virus<br /> | ||
**[[6usm]] – NS1 + MBP – Human parvovirus<br /> | **[[6usm]] – NS1 + MBP – Human parvovirus<br /> | ||
| - | **[6sx0]], [[6zlc]] – IvNS1 RNA-binding domain + RNA<br /> | + | **[[6sx0]], [[6zlc]] – IvNS1 RNA-binding domain + RNA<br /> |
**[[6sx2]] – IvNS1 RNA-binding domain (mutant) + RNA<br /> | **[[6sx2]] – IvNS1 RNA-binding domain (mutant) + RNA<br /> | ||
**[[6e5u]] – IvNS1 + NXF1 + NXT1<br /> | **[[6e5u]] – IvNS1 + NXF1 + NXT1<br /> | ||
| Line 85: | Line 93: | ||
*Nonstructural protein NS3 from SARS CoV-2; Domain 1564-1878 (papain-like protease), [[3241-3546 (3C-like proteinase) see [[Virus protease 3D structures]] | *Nonstructural protein NS3 from SARS CoV-2; Domain 1564-1878 (papain-like protease), [[3241-3546 (3C-like proteinase) see [[Virus protease 3D structures]] | ||
| - | **[[2jzd | + | **[[2jzd]], [[2jze]], [[2jzf]], [[2rnk]] – SvNS3 residues 527-651 – NMR<br /> |
**[[7kag]] – Sv2NS3 Ubl1 domain 819-929<br /> | **[[7kag]] – Sv2NS3 Ubl1 domain 819-929<br /> | ||
**[[6vxs]], [[6wcf]], [[6wen]], [[6wey]], [[6ywk]], [[6ywm]], [[7kg3]], [[7kqo]], [[7kqw]], [[7kr0]], [[7kr1]] – Sv2NS3 macrodomain 1025-1191<br /> | **[[6vxs]], [[6wcf]], [[6wen]], [[6wey]], [[6ywk]], [[6ywm]], [[7kg3]], [[7kqo]], [[7kqw]], [[7kr0]], [[7kr1]] – Sv2NS3 macrodomain 1025-1191<br /> | ||
| Line 99: | Line 107: | ||
**[[6yxj]] – Sv2NS3 macrodomain II 1207-1344 + Paip1<br /> | **[[6yxj]] – Sv2NS3 macrodomain II 1207-1344 + Paip1<br /> | ||
| - | *Other nonstructural protein from SARS CoV-2 | + | *Other nonstructural protein from SARS CoV-2; SV2NS14 is proofreading exoribonuclease |
**[[6zlw]], [[6zoj]], [[6zok]], [[6zol]], [[7k5i]] – Sv2NS1 in human 40S ribosome – Cryo EM<br /> | **[[6zlw]], [[6zoj]], [[6zok]], [[6zol]], [[7k5i]] – Sv2NS1 in human 40S ribosome – Cryo EM<br /> | ||
| Line 120: | Line 128: | ||
**[[6nur]], [[6nus]] – Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 – Cryo EM<br /> | **[[6nur]], [[6nus]] – Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 – Cryo EM<br /> | ||
**[[5rob]], [[6jyt]], [[6zsl]], [[7nio]] – SvNS13 <br /> | **[[5rob]], [[6jyt]], [[6zsl]], [[7nio]] – SvNS13 <br /> | ||
| - | **[[7diy]] – | + | **[[5smk]], [[7qgi]] – proofreading exoribonuclease <br /> |
| + | **[[7diy]] – proofreading exoribonuclease residues 5926-6214 + Sv2NS10 residues 4254-4392<br /> | ||
**[[6vww]], [[6w01]], [[6xdh]], [[7kf4]] – Sv2NS15 residues 6453-6798<br /> | **[[6vww]], [[6w01]], [[6xdh]], [[7kf4]] – Sv2NS15 residues 6453-6798<br /> | ||
**[[6w4h]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392<br /> | **[[6w4h]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392<br /> | ||
| Line 135: | Line 144: | ||
**[[7kri]] – Sv2NS9 residues 4141-4253 + pyrimidine derivative<br /> | **[[7kri]] – Sv2NS9 residues 4141-4253 + pyrimidine derivative<br /> | ||
**[[7mc5]], [[7mc6]] – Sv2NS10 residues 4254-4392 + proofreading exoribonuclease<br /> | **[[7mc5]], [[7mc6]] – Sv2NS10 residues 4254-4392 + proofreading exoribonuclease<br /> | ||
| + | **[[7r2v]] – proofreading exoribonuclease + SAH<br /> | ||
| + | **[[7qif]] – proofreading exoribonuclease + MeGpppG<br /> | ||
| + | **[[5skw]], [[5skx]], [[5sky]], [[5skz]], [[5sl0]], [[5sl1]], [[5sl2]], [[5sl3]], [[5sl4]], [[5sl5]], [[5sl6]], [[5sl7]], [[5sl8]], [[5sl9]], [[5sla]], [[5slb]], [[5slc]], [[5sld]], [[5sle]], [[5slf]], [[5slg]], [[5slh]], [[5sli]], [[5slj]], [[5slk]], [[5sll]], [[5slm]], [[5sln]], [[5slo]], [[5slp]], [[5slq]], [[5slr]], [[5sls]], [[5slt]], [[5slu]] [[5slv]], [[5slw]], [[5slx]], [[5sly]], [[5slz]], [[5sm0]] [[5sm1]], [[5sm2]], [[5sm3]] [[5sm4]], [[5sm5]], [[[5sm6]] [[5sm7]], [[5sm8]], [5sm9]] [[5sma]], [[5smib], [[5smc]] [[5smd]], [[5sme]], [[5smf]], [[5smg]] [[5smh]], [[5smi]], [[5smk]] – proofreading exoribonuclease + inhibitor<br /> | ||
**[[7n0b]], [[7n0c]], [[7n0d]] – Sv2NS10 residues 4254-4392 + proofreading exoribonuclease + RNA – Cryo EM<br /> | **[[7n0b]], [[7n0c]], [[7n0d]] – Sv2NS10 residues 4254-4392 + proofreading exoribonuclease + RNA – Cryo EM<br /> | ||
**[[5rl6]], [[5rl7]], [[5rl8]], [[5rl9]], [[5rlc]], [[5rld]], [[5rle]], [[5rlf]], [[5rlg]], [[5rlh]], [[5rli]], [[5rlj]], [[5rlk]], [[5rll]], [[5rlm]], [[5rln]], [[5rlo]], [[5rlp]], [[5rlq]], [[5rlr]], [[5rls]], [[5rlt]], [[5rlu]], [[5rlv]], [[5rlw]], [[5rly]], [[5rlz]], [[5rm0]], [[5rm1]], [[5rm2]], [[5rm3]], [[5rm4]], [[5rm5]], [[5rm6]], [[5rm7]], [[5rm8]], [[5rm9]], [[5rma]], [[5rmb]], [[5rmc]], [[5rmd]], [[5rme]], [[5rmf]], [[5rmg]], [[5rmh]], [[5rmi]], [[5rmj]], [[5rmk]] [[5rml]], [[5rmm]], [[7nng]] – SvNS13 + inhibitor<br /> | **[[5rl6]], [[5rl7]], [[5rl8]], [[5rl9]], [[5rlc]], [[5rld]], [[5rle]], [[5rlf]], [[5rlg]], [[5rlh]], [[5rli]], [[5rlj]], [[5rlk]], [[5rll]], [[5rlm]], [[5rln]], [[5rlo]], [[5rlp]], [[5rlq]], [[5rlr]], [[5rls]], [[5rlt]], [[5rlu]], [[5rlv]], [[5rlw]], [[5rly]], [[5rlz]], [[5rm0]], [[5rm1]], [[5rm2]], [[5rm3]], [[5rm4]], [[5rm5]], [[5rm6]], [[5rm7]], [[5rm8]], [[5rm9]], [[5rma]], [[5rmb]], [[5rmc]], [[5rmd]], [[5rme]], [[5rmf]], [[5rmg]], [[5rmh]], [[5rmi]], [[5rmj]], [[5rmk]] [[5rml]], [[5rmm]], [[7nng]] – SvNS13 + inhibitor<br /> | ||
Current revision
3D Structures of Nonstructural protein
Updated on 03-April-2024
