7sx1
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7sx1 is ON HOLD Authors: Romero, J.M. Description: human triosephosphate isomerase mutant v154m Category: Unreleased Structures [[Category: Rom...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==human triosephosphate isomerase mutant v154m== | |
| - | + | <StructureSection load='7sx1' size='340' side='right'caption='[[7sx1]], [[Resolution|resolution]] 2.23Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7sx1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SX1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr> |
| - | [[Category: Romero | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sx1 OCA], [https://pdbe.org/7sx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sx1 RCSB], [https://www.ebi.ac.uk/pdbsum/7sx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sx1 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[https://omim.org/entry/190450 190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Romero JM]] | ||
Current revision
human triosephosphate isomerase mutant v154m
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