7fj0
From Proteopedia
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<StructureSection load='7fj0' size='340' side='right'caption='[[7fj0]]' scene=''> | <StructureSection load='7fj0' size='340' side='right'caption='[[7fj0]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[7fj0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FJ0 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fj0 OCA], [https://pdbe.org/7fj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fj0 RCSB], [https://www.ebi.ac.uk/pdbsum/7fj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fj0 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=53D:1-cyclopropyl-N-[3-(dimethylamino)propyl]-7-(4-ethylpiperazin-1-yl)-6-fluoranyl-4-oxidanylidene-quinoline-3-carboxamide'>53D</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fj0 OCA], [https://pdbe.org/7fj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fj0 RCSB], [https://www.ebi.ac.uk/pdbsum/7fj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fj0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Interaction analysis between small molecules and RNA as well as structure determination of RNA-small molecule complexes will be the clues to search for compounds that bind to specific mRNA or non-coding RNA in drug discovery. In this study, the RNA binding ability of a fluoroquinolone derivative, KG022, was examined against single-residue bulge-containing hairpin RNAs as RNA models. NMR analysis indicated that KG022 interacts with the RNAs in the vicinity of the bulge residue, with preferring C and G as the bulge residues. The solution structures of the RNA-KG022 complexes showed that the KG022 binds to the RNAs at the bulge-out regions. Each substituent in KG022 interacts specific position of RNAs around the bulge-out region probably contributing the specificity of the binding. This work provides a novel member for the RNA-targeted small molecules. | ||
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| + | Interaction between a fluoroquinolone derivative and RNAs with a single bulge.,Nagano K, Kamimura T, Kawai G J Biochem. 2021 Nov 16. pii: 6429710. doi: 10.1093/jb/mvab124. PMID:34791286<ref>PMID:34791286</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7fj0" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
[[Category: Kamimura T]] | [[Category: Kamimura T]] | ||
[[Category: Kawai G]] | [[Category: Kawai G]] | ||
[[Category: Nagano K]] | [[Category: Nagano K]] | ||
Current revision
Interaction between a fluoroquinolone derivative and RNAs with a single bulge
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