2ck5
From Proteopedia
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==Solution structure of Delta 1-7 aOSK1== | ==Solution structure of Delta 1-7 aOSK1== | ||
| - | <StructureSection load='2ck5' size='340' side='right'caption='[[2ck5 | + | <StructureSection load='2ck5' size='340' side='right'caption='[[2ck5]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ck5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CK5 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2ck5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthochirus_scrobiculosus Orthochirus scrobiculosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CK5 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ck5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ck5 OCA], [https://pdbe.org/2ck5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ck5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ck5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ck5 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ck5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ck5 OCA], [https://pdbe.org/2ck5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ck5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ck5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ck5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/KAX37_ORTSC KAX37_ORTSC] Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=0.6nM), Kv1.2/KCNA2 (IC(50)=5.4nM), Kv1.3/KCNA3 (IC(50)=0.014nM) potently, and moderately block intermediate conductance calcium-activated potassium channels KCa3.1/KCNN4 (IC(50)=225nM). At high concentration (2 mM), is also active on Kv1.6/KCNA6 and Shaker IR.[REFERENCE:1]<ref>PMID:15588251</ref> | |
==See Also== | ==See Also== | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Alphonse | + | [[Category: Orthochirus scrobiculosus]] |
| - | [[Category: Bernard | + | [[Category: Alphonse S]] |
| - | [[Category: Darbon | + | [[Category: Bernard C]] |
| - | [[Category: Mouhat | + | [[Category: Darbon H]] |
| - | [[Category: Sabatier | + | [[Category: Mouhat S]] |
| - | + | [[Category: Sabatier JM]] | |
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Current revision
Solution structure of Delta 1-7 aOSK1
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