2khn

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==NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.==
==NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.==
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<StructureSection load='2khn' size='340' side='right'caption='[[2khn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2khn' size='340' side='right'caption='[[2khn]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2khn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KHN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2khn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KHN FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ITSN1, ITSN, SH3D1A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2khn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khn OCA], [https://pdbe.org/2khn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2khn RCSB], [https://www.ebi.ac.uk/pdbsum/2khn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2khn ProSAT], [https://www.topsan.org/Proteins/NESGC/2khn TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2khn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khn OCA], [https://pdbe.org/2khn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2khn RCSB], [https://www.ebi.ac.uk/pdbsum/2khn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2khn ProSAT], [https://www.topsan.org/Proteins/NESGC/2khn TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
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[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Acton, T B]]
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[[Category: Acton TB]]
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[[Category: Everett, J K]]
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[[Category: Everett JK]]
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[[Category: Foote, E L]]
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[[Category: Foote EL]]
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[[Category: Garcia, E]]
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[[Category: Garcia E]]
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[[Category: Ghosh, A]]
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[[Category: Ghosh A]]
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[[Category: Janjua, H]]
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[[Category: Janjua H]]
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[[Category: Mills, J L]]
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[[Category: Mills JL]]
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[[Category: Montelione, G T]]
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[[Category: Montelione GT]]
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[[Category: Structural genomic]]
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[[Category: Shastry R]]
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[[Category: Shastry, R]]
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[[Category: Szyperski T]]
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[[Category: Szyperski, T]]
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[[Category: Xiao R]]
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[[Category: Xiao, R]]
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[[Category: Zhang Q]]
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[[Category: Zhang, Q]]
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[[Category: Alternative splicing]]
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[[Category: Calcium]]
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[[Category: Cell junction]]
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[[Category: Cell projection]]
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[[Category: Coiled coil]]
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[[Category: Endocytosis]]
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[[Category: Gft nmr]]
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[[Category: High throughput]]
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[[Category: Human intersectin-1]]
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[[Category: Membrane]]
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[[Category: Nesgc]]
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[[Category: Phosphoprotein]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Sh3 domain]]
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[[Category: Signaling protein]]
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[[Category: Synapse]]
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[[Category: Synaptosome]]
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Current revision

NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.

PDB ID 2khn

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OCA

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