2kka
From Proteopedia
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==Human telomere DNA two-tetrad quadruplex structure in K+ solution== | ==Human telomere DNA two-tetrad quadruplex structure in K+ solution== | ||
| - | <StructureSection load='2kka' size='340' side='right'caption='[[2kka | + | <StructureSection load='2kka' size='340' side='right'caption='[[2kka]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kka]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KKA FirstGlance]. <br> | <table><tr><td colspan='2'>[[2kka]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KKA FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kka OCA], [https://pdbe.org/2kka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kka RCSB], [https://www.ebi.ac.uk/pdbsum/2kka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kka ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kka OCA], [https://pdbe.org/2kka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kka RCSB], [https://www.ebi.ac.uk/pdbsum/2kka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kka ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K(+) solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5'-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations. | ||
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| - | Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures.,Zhang Z, Dai J, Veliath E, Jones RA, Yang D Nucleic Acids Res. 2010 Jan;38(3):1009-21. Epub 2009 Nov 27. PMID:19946019<ref>PMID:19946019</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2kka" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Dai | + | [[Category: Dai J]] |
| - | [[Category: Yang | + | [[Category: Yang D]] |
| - | [[Category: Zhang | + | [[Category: Zhang Z]] |
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Current revision
Human telomere DNA two-tetrad quadruplex structure in K+ solution
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Categories: Large Structures | Dai J | Yang D | Zhang Z
