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P53 3D structures
From Proteopedia
(Difference between revisions)
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* p53 DNA-binding domain (residues 94-292) | * p53 DNA-binding domain (residues 94-292) | ||
| - | ** [[2xwr]], [[2ocj]], [[2ybg]] – h-p53 DBD – human<BR /> | + | ** [[2xwr]], [[2ocj]], [[2ybg]], [[8f2h]], [8f2i]] – h-p53 DBD – human<BR /> |
** [[2fej]] - h-p53 DBD - NMR<BR /> | ** [[2fej]] - h-p53 DBD - NMR<BR /> | ||
| - | ** [[2wgx]], [[3d05]], [[3d06]], [[3d07]], [[3d08]], [[3d09]], [[2pcx]], [[2j1w]], [[2j1x]], [[2j1y]], [[2j1z]], [[2j20]], [[2j21]], [[2bim]], [[2bin]], [[2bio]], [[2bip]], [[2biq]], [[1uol]], [[4kvp]], [[4lo9]], [[4loe]], [[4lof]], [[4ibq]], [[4ibs]], [[4ibt]], [[4iby]], [[4ibz]], [[4ijt]], [[4mzi]], [[5lap]], [[6ff9]], [[6shz]], [[6si0]], [[6si1]], [[6sl6]], [[7dhy]], [[7dhz]] - h-p53 DBD (mutant) <BR /> | + | ** [[2wgx]], [[3d05]], [[3d06]], [[3d07]], [[3d08]], [[3d09]], [[2pcx]], [[2j1w]], [[2j1x]], [[2j1y]], [[2j1z]], [[2j20]], [[2j21]], [[2bim]], [[2bin]], [[2bio]], [[2bip]], [[2biq]], [[1uol]], [[4kvp]], [[4lo9]], [[4loe]], [[4lof]], [[4ibq]], [[4ibs]], [[4ibt]], [[4iby]], [[4ibz]], [[4ijt]], [[4mzi]], [[5lap]], [[6ff9]], [[6shz]], [[6si0]], [[6si1]], [[6sl6]], [[7dhy]], [[7dhz]], [[7eax]], [[7eeu]], [[7v97]], [[8e7a]], [[8e7b]] - h-p53 DBD (mutant) <BR /> |
** [[2ioi]], [[2ioo]], [[1hu8]] – m-p53 DBD – mouse<BR /> | ** [[2ioi]], [[2ioo]], [[1hu8]] – m-p53 DBD – mouse<BR /> | ||
** [[1t4w]] – p53-like DBD – ''Caenoharbditis elegans'' | ** [[1t4w]] – p53-like DBD – ''Caenoharbditis elegans'' | ||
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** [[3igk]], [[3igl]], [[3kz8]], [[3kmd]], [[2ac0]], [[2ady]], [[2ahi]], [[2ata]], [[1tsr]], [[1tup]], [[4hje]], [[5bua]], [[6fj5]], [[5mg7]], [[5mf7]], [[5mcw]], [[5mcu]], [[5mct]], [[5lgy]] – h-p53 DBD + DNA<BR /> | ** [[3igk]], [[3igl]], [[3kz8]], [[3kmd]], [[2ac0]], [[2ady]], [[2ahi]], [[2ata]], [[1tsr]], [[1tup]], [[4hje]], [[5bua]], [[6fj5]], [[5mg7]], [[5mf7]], [[5mcw]], [[5mcu]], [[5mct]], [[5lgy]] – h-p53 DBD + DNA<BR /> | ||
| - | ** [[3d0a]], [[3ts8]], [[4ibu]], [[4ibv]], [[4ibw]] - h-p53 DBD (mutant) + DNA<BR /> | + | ** [[3d0a]], [[3ts8]], [[4ibu]], [[4ibv]], [[4ibw]], [[7b47]], [[7b48]], [[7b49]], [[7b4a]], [[7b4b]], [[7b4c]], [[7b4d]], [[7b4e]], [[7b4f]], [[7b4h]], [[7b4n]], [[7eds]] - h-p53 DBD (mutant) + DNA<BR /> |
** [[3q05]], [[3q06]] - h-p53 DBD + TD + DNA<br /> | ** [[3q05]], [[3q06]] - h-p53 DBD + TD + DNA<br /> | ||
** [[3exj]], [[3exl]], [[2p52]], [[2geq]] – m-p53 DBD + DNA | ** [[3exj]], [[3exl]], [[2p52]], [[2geq]] – m-p53 DBD + DNA | ||
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** [[2x0u]], [[2x0v]], [[2x0w]], [[4agl]], [[4agm]], [[4agn]], [[4ago]], [[4agp]], [[4agq]], [[5aol]], [[5aoj]] – h-p53 DBD (mutant) + benzene derivative<BR /> | ** [[2x0u]], [[2x0v]], [[2x0w]], [[4agl]], [[4agm]], [[4agn]], [[4ago]], [[4agp]], [[4agq]], [[5aol]], [[5aoj]] – h-p53 DBD (mutant) + benzene derivative<BR /> | ||
| - | ** [[3zme]] - h-p53 DBD (mutant) + pyrazol derivative<br /> | + | ** [[3zme]], [[8a92]] - h-p53 DBD (mutant) + pyrazol derivative<br /> |
| - | **[[5aoi]], [[5ab9]] - h-p53 DBD (mutant) + indole derivative<br /> | + | **[[8dc4]] - h-p53 DBD (mutant) + carbazole<br /> |
| + | **[[5aoi]], [[5ab9]], [[8dc6]], [[8dc7]], [[8dc8]] - h-p53 DBD (mutant) + indole derivative<br /> | ||
** [[2vuk]] - h-p53 DBD + drug<BR /> | ** [[2vuk]] - h-p53 DBD + drug<BR /> | ||
**[[5g4o]], [[5g4n]], [[5g4m]], [[5aom]], [[5aok]], [[5aba]], [[5a7b]], [[5o1i]], [[5o1h]], [[5o1g]], [[5o1f]], [[5o1e]], [[5o1a]], [[5o1b]], [[5o1c]], [[5o1d]] - h-p53 DBD (mutant) + drug<br /> | **[[5g4o]], [[5g4n]], [[5g4m]], [[5aom]], [[5aok]], [[5aba]], [[5a7b]], [[5o1i]], [[5o1h]], [[5o1g]], [[5o1f]], [[5o1e]], [[5o1a]], [[5o1b]], [[5o1c]], [[5o1d]] - h-p53 DBD (mutant) + drug<br /> | ||
| - | **[[6gff]], [[6gge]], [[6ggd]], [[6ggc]], [[6ggb]], [[6gga]], [[6si3]], [[6si4]] - h-p53 DBD (mutant) + stabilizer<br /> | + | **[[6gff]], [[6gge]], [[6ggd]], [[6ggc]], [[6ggb]], [[6gga]], [[6si3]], [[6si4]], [[8a31]], [[8a32]] - h-p53 DBD (mutant) + stabilizer<br /> |
** [[2iom]] - m-p53 DBD + propanol | ** [[2iom]] - m-p53 DBD + propanol | ||
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**[[6rz3]] - h-p53 DBD + IASPP<br /> | **[[6rz3]] - h-p53 DBD + IASPP<br /> | ||
**[[7dvd]] - h-p53 DBD + PUMA<br /> | **[[7dvd]] - h-p53 DBD + PUMA<br /> | ||
| + | **[[8hll]], [[8hlm]], [[8hln]] - h-p53 DBD + Bcl-2<br /> | ||
| + | **[[7ygi]] - h-p53 DBD + azurin<br /> | ||
* p53 transactivation domain (residues 15-29) | * p53 transactivation domain (residues 15-29) | ||
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** [[1ycq]], [[1ycr]] - h-p53 TAD + MDM2 protein<br /> | ** [[1ycq]], [[1ycr]] - h-p53 TAD + MDM2 protein<br /> | ||
** [[2l14]] – h-p53 TAD + CREB-binding protein<br /> | ** [[2l14]] – h-p53 TAD + CREB-binding protein<br /> | ||
| - | ** [[2gs0]] – h-p53 TAD + RNA polymerase II transcription factor | + | ** [[2gs0]] – h-p53 TAD + RNA polymerase II transcription factor<br /> |
| + | **[[7nmi]] - h-p53 TAD + S110P/ANXA2<br /> | ||
* p53 tetramerization domain (residues 326-356) | * p53 tetramerization domain (residues 326-356) | ||
