1fue

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[[Image:1fue.gif|left|200px]]
 
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==FLAVODOXIN FROM HELICOBACTER PYLORI==
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The line below this paragraph, containing "STRUCTURE_1fue", creates the "Structure Box" on the page.
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<StructureSection load='1fue' size='340' side='right'caption='[[1fue]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fue]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FUE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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{{STRUCTURE_1fue| PDB=1fue | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fue OCA], [https://pdbe.org/1fue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fue RCSB], [https://www.ebi.ac.uk/pdbsum/1fue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fue ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FLAV_HELPJ FLAV_HELPJ] Low-potential electron donor to a number of redox enzymes (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fu/1fue_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fue ConSurf].
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<div style="clear:both"></div>
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'''FLAVODOXIN FROM HELICOBACTER PYLORI'''
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==See Also==
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*[[Flavodoxin 3D structures|Flavodoxin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The redox protein flavodoxin has been shown earlier to be reduced by the pyruvate-oxidoreductase (POR) enzyme complex of Helicobacter pylori, and also was proposed to be involved in the pathogenesis of gastric mucosa-associated lymphoid-tissue lymphoma (MALToma). Here, we report its X-ray structure, which is similar to flavodoxins of other bacteria and cyanobacteria. However, H. pylori flavodoxin has an alanine residue near the isoalloxazine ring of its cofactor flavin mononucleotide (FMN), while the other previously crystallized flavodoxins have a larger hydrophobic residue at this position. This creates a solute filled hole near the FMN cofactor of H. pylori flavodoxin. We also show that flavodoxin is essential for the survival of H. pylori, and conclude that its structure can be used as a starting point for the modeling of an inhibitor for the interaction between the POR-enzyme complex and flavodoxin.
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==About this Structure==
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1FUE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FUE OCA].
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==Reference==
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Crystal structure of oxidized flavodoxin, an essential protein in Helicobacter pylori., Freigang J, Diederichs K, Schafer KP, Welte W, Paul R, Protein Sci. 2002 Feb;11(2):253-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11790835 11790835]
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[[Category: Helicobacter pylori]]
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[[Category: Single protein]]
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[[Category: Diederichs, K.]]
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[[Category: Freigang, J.]]
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[[Category: Paul, R.]]
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[[Category: Schaefer, K P.]]
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[[Category: Welte, W.]]
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[[Category: Flavoprotein]]
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[[Category: Fmn]]
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[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:46:38 2008''
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[[Category: Large Structures]]
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[[Category: Diederichs K]]
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[[Category: Freigang J]]
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[[Category: Paul R]]
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[[Category: Schaefer KP]]
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[[Category: Welte W]]

Current revision

FLAVODOXIN FROM HELICOBACTER PYLORI

PDB ID 1fue

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