This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7qdp
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7qdp is ON HOLD until sometime in the future Authors: Pannecoucke, E., Savvides, S.N. Description: Crystal structure of FLT3 T343I in complex with ...) |
|||
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of FLT3 T343I in complex with the canonical ligand FL== | |
| - | + | <StructureSection load='7qdp' size='340' side='right'caption='[[7qdp]], [[Resolution|resolution]] 3.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7qdp]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QDP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.691Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[Category: Pannecoucke | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qdp OCA], [https://pdbe.org/7qdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qdp RCSB], [https://www.ebi.ac.uk/pdbsum/7qdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qdp ProSAT]</span></td></tr> |
| - | [[Category: Savvides | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FLT3L_HUMAN FLT3L_HUMAN] Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pannecoucke E]] | ||
| + | [[Category: Savvides SN]] | ||
Current revision
Crystal structure of FLT3 T343I in complex with the canonical ligand FL
| |||||||||||
