7w68

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m (Protected "7w68" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 7w68 is ON HOLD
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==human single hexameric Mcm2-7 complex==
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<StructureSection load='7w68' size='340' side='right'caption='[[7w68]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
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Authors: Xu, N.N., Lin, Q.P., Liu, C.D., Tian, H.L., Xiang, Y., Zhu, G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7w68]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W68 FirstGlance]. <br>
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Description: human single hexameric Mcm2-7 complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w68 OCA], [https://pdbe.org/7w68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w68 RCSB], [https://www.ebi.ac.uk/pdbsum/7w68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w68 ProSAT]</span></td></tr>
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[[Category: Zhu, G]]
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</table>
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[[Category: Lin, Q.P]]
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== Disease ==
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[[Category: Xiang, Y]]
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[https://www.uniprot.org/uniprot/MCM4_HUMAN MCM4_HUMAN] Primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency. The disease is caused by mutations affecting the gene represented in this entry.
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[[Category: Liu, C.D]]
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== Function ==
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[[Category: Tian, H.L]]
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[https://www.uniprot.org/uniprot/MCM4_HUMAN MCM4_HUMAN] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.<ref>PMID:16899510</ref> <ref>PMID:9305914</ref>
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[[Category: Xu, N.N]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Lin QP]]
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[[Category: Liu CD]]
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[[Category: Tian HL]]
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[[Category: Xiang Y]]
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[[Category: Xu NN]]
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[[Category: Zhu G]]

Current revision

human single hexameric Mcm2-7 complex

PDB ID 7w68

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OCA

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