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6zv0
From Proteopedia
(Difference between revisions)
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==TFIIS N-terminal domain (TND) from human LEDGF/p75== | ==TFIIS N-terminal domain (TND) from human LEDGF/p75== | ||
| - | <StructureSection load='6zv0' size='340' side='right'caption='[[6zv0 | + | <StructureSection load='6zv0' size='340' side='right'caption='[[6zv0]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6zv0]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZV0 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6zv0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZV0 FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zv0 OCA], [https://pdbe.org/6zv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zv0 RCSB], [https://www.ebi.ac.uk/pdbsum/6zv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zv0 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zv0 OCA], [https://pdbe.org/6zv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zv0 RCSB], [https://www.ebi.ac.uk/pdbsum/6zv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zv0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN] Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN] Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.<ref>PMID:15642333</ref> | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Veverka | + | [[Category: Veverka V]] |
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Current revision
TFIIS N-terminal domain (TND) from human LEDGF/p75
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