Peptidyl-tRNA hydrolase
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
<StructureSection load='' size='350' side='right' caption='Structure of peptidyl-tRNA hydrolase complex with tRNA CCA acceptor domain (PDB entry [[3vjr]])' scene='55/551222/Cv/1'> | <StructureSection load='' size='350' side='right' caption='Structure of peptidyl-tRNA hydrolase complex with tRNA CCA acceptor domain (PDB entry [[3vjr]])' scene='55/551222/Cv/1'> | ||
== Function == | == Function == | ||
| - | '''Peptidyl-tRNA hydrolase''' (PTH) is a bacterial enzyme which cleaves peptidyl-tRNA to free peptide and tRNA<ref>PMID:16849786</ref>. PTH catalyzes the reaction in cases of aborted translation for recycling the tRNA for further rounds of protein synthesis. PTH is essential for bacterial viability. | + | '''Peptidyl-tRNA hydrolase''' (PTH) is a bacterial enzyme which cleaves peptidyl-tRNA to free peptide and tRNA<ref>PMID:16849786</ref>. PTH catalyzes the reaction in cases of aborted translation for recycling the tRNA for further rounds of protein synthesis. PTH is essential for bacterial viability.rew)]]. |
| + | |||
| + | See also [[Peptidyl-tRNA hydrolase 2, mitochondrial (Hebrew)]]. | ||
== Structural highlights == | == Structural highlights == | ||
| Line 14: | Line 16: | ||
*Peptidyl-tRNA hydrolase | *Peptidyl-tRNA hydrolase | ||
| + | **[[1q7s]] – hPTH residues 63-179– human<BR /> | ||
**[[2pth]] – EcPTH – ''Escherichia coli''<BR /> | **[[2pth]] – EcPTH – ''Escherichia coli''<BR /> | ||
**[[3ofv]] – EcPTH (mutant)<BR /> | **[[3ofv]] – EcPTH (mutant)<BR /> | ||
| Line 45: | Line 48: | ||
**[[4jx9]] – AbPTH + uridine<BR /> | **[[4jx9]] – AbPTH + uridine<BR /> | ||
**[[4qbk]] – PaPTH + adenosine derivative<BR /> | **[[4qbk]] – PaPTH + adenosine derivative<BR /> | ||
| + | **[[8axp]] – PTH + thyazole derivative – ''Neisseria gonorrhoeae''<BR /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
3D Structures of peptidyl-tRNA hydrolase
Updated on 05-January-2025
References
- ↑ Das G, Varshney U. Peptidyl-tRNA hydrolase and its critical role in protein biosynthesis. Microbiology. 2006 Aug;152(Pt 8):2191-5. PMID:16849786 doi:http://dx.doi.org/10.1099/mic.0.29024-0
- ↑ Ito K, Murakami R, Mochizuki M, Qi H, Shimizu Y, Miura KI, Ueda T, Uchiumi T. Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase. Nucleic Acids Res. 2012 Aug 25. PMID:22923517 doi:10.1093/nar/gks790
