2z5c

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Current revision (13:22, 1 November 2023) (edit) (undo)
 
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<StructureSection load='2z5c' size='340' side='right'caption='[[2z5c]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='2z5c' size='340' side='right'caption='[[2z5c]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2z5c]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2z5c]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5C FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2z5b|2z5b]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5c OCA], [https://pdbe.org/2z5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5c RCSB], [https://www.ebi.ac.uk/pdbsum/2z5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5c OCA], [https://pdbe.org/2z5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5c RCSB], [https://www.ebi.ac.uk/pdbsum/2z5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/POC4_YEAST POC4_YEAST]] Involved in 20S proteasome assembly, facilitating the alpha-ring formation. Involved in maintenance of telomere length.<ref>PMID:15161972</ref> <ref>PMID:17707236</ref> <ref>PMID:18278057</ref> [[https://www.uniprot.org/uniprot/PSA5_YEAST PSA5_YEAST]] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. [[https://www.uniprot.org/uniprot/POC3_YEAST POC3_YEAST]] Involved in 20S proteasome assembly, facilitating the alpha-ring formation.<ref>PMID:17707236</ref> <ref>PMID:18278057</ref>
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[https://www.uniprot.org/uniprot/POC4_YEAST POC4_YEAST] Involved in 20S proteasome assembly, facilitating the alpha-ring formation. Involved in maintenance of telomere length.<ref>PMID:15161972</ref> <ref>PMID:17707236</ref> <ref>PMID:18278057</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 18824]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Proteasome endopeptidase complex]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Hayashi, H]]
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[[Category: Hayashi H]]
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[[Category: Hirano, Y]]
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[[Category: Hirano Y]]
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[[Category: Kameyama, T]]
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[[Category: Kameyama T]]
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[[Category: Kasahara, M]]
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[[Category: Kasahara M]]
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[[Category: Kato, K]]
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[[Category: Kato K]]
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[[Category: Kishimoto, T]]
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[[Category: Kishimoto T]]
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[[Category: Kurimoto, E]]
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[[Category: Kurimoto E]]
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[[Category: Mizushima, T]]
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[[Category: Mizushima T]]
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[[Category: Murata, S]]
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[[Category: Murata S]]
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[[Category: Okamoto, K]]
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[[Category: Okamoto K]]
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[[Category: Sakata, E]]
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[[Category: Sakata E]]
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[[Category: Suzuki, A]]
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[[Category: Suzuki A]]
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[[Category: Tanaka, K]]
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[[Category: Tanaka K]]
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[[Category: Yamane, T]]
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[[Category: Yamane T]]
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[[Category: Yashiroda, H]]
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[[Category: Yashiroda H]]
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[[Category: Chaperone]]
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[[Category: Chaperone-hydrolase complex]]
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[[Category: Proteasome]]
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[[Category: S. cerevisiae]]
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Current revision

Crystal Structure of a Novel Chaperone Complex for Yeast 20S Proteasome Assembly

PDB ID 2z5c

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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