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Phospholipase D

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== Structural highlights ==
== Structural highlights ==
The <scene name='74/749398/Cv/3'>active site of PLD contains the substrate derivative dibutyrylphosphatidylcholine</scene><ref>PMID:15165852</ref>. Water molecule are shown as red sphere.
The <scene name='74/749398/Cv/3'>active site of PLD contains the substrate derivative dibutyrylphosphatidylcholine</scene><ref>PMID:15165852</ref>. Water molecule are shown as red sphere.
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</StructureSection>
 
==3D structures of phospholipase D==
==3D structures of phospholipase D==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Phospholipase D 3D structures]]
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[[6u8z]] – hPLD1 catalytic domain 330-500, 643-1074 – human<br />
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</StructureSection>
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[[6ohr]] – hPLD1 catalytic domain + inhibitor<br />
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[[6ohm]], [[6oho]] – hPLD2 catalytic domain 294-933<br />
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[[6ohq]], [[6ohs]], [[6ohp]] – hPLD2 catalytic domain + inhibitor<br />
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[[4rw3]] – bsPLD – brown spider<br />
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[[4rw5]] – bsPLD (mutant)<br />
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[[3rlg]], [[3rlh]] – PLD (mutant) – ''Loxosceles intemedia''<br />
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[[4q6x]] – PLD – cave spider<br />
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[[2ze4]], [[1v0r]], [[1v0s]], [[1f0i]] – SaPLD – ''Streptomyces antibioticus''<br />
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[[7jrb]] – SaPLD (mutant) <br />
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[[1v0v]], [[1v0w]] – SaPLD + phosphite<br />
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[[1v0y]] – SaPLD + phosphatidylcholine derivative<br />
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[[2ze9]] – SaPLD (mutant) + phosphatidylcholine<br />
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[[1v0t]], [[1v0u]] – SaPLD + glycerophosphate<br />
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[[7jrc]] – SaPLD (mutant) + phosphate<br />
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[[7js5]], [[7js7]] – SaPLD (mutant) + inositol phosphate<br />
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[[7jru]], [[7jrv]], [[7jrw]] – SaPLD (mutant) + phosphatidic acid<br />
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[[6kz9]] – AtPLD a 1 – ''Arabidopsis thaliana''<br />
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[[6kz8]] – AtPLD a 1 + phosphatidic acid <br />
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== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Phospholipase D complex with substrate dibutyrylphosphatidylcholine (PDB code 1v0y)

Drag the structure with the mouse to rotate

References

  1. ↑ McDermott M, Wakelam MJ, Morris AJ. Phospholipase D. Biochem Cell Biol. 2004 Feb;82(1):225-53. PMID:15052340 doi:http://dx.doi.org/10.1139/o03-079
  2. ↑ Oliveira TG, Di Paolo G. Phospholipase D in brain function and Alzheimer's disease. Biochim Biophys Acta. 2010 Aug;1801(8):799-805. doi:, 10.1016/j.bbalip.2010.04.004. Epub 2010 Apr 23. PMID:20399893 doi:http://dx.doi.org/10.1016/j.bbalip.2010.04.004
  3. ↑ Leiros I, McSweeney S, Hough E. The reaction mechanism of phospholipase D from Streptomyces sp. strain PMF. Snapshots along the reaction pathway reveal a pentacoordinate reaction intermediate and an unexpected final product. J Mol Biol. 2004 Jun 11;339(4):805-20. PMID:15165852 doi:http://dx.doi.org/10.1016/j.jmb.2004.04.003

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