7na8
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| - | ==== | + | ==Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist== |
| - | <StructureSection load='7na8' size='340' side='right'caption='[[7na8]]' scene=''> | + | <StructureSection load='7na8' size='340' side='right'caption='[[7na8]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7na8]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NA8 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7na8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7na8 OCA], [https://pdbe.org/7na8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7na8 RCSB], [https://www.ebi.ac.uk/pdbsum/7na8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7na8 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1KD:1-(methanesulfonyl)-1-(2-methyl-L-alanyl-O-benzyl-D-seryl)-1,2-dihydrospiro[indole-3,4-piperidine]'>1KD</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7na8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7na8 OCA], [https://pdbe.org/7na8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7na8 RCSB], [https://www.ebi.ac.uk/pdbsum/7na8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7na8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Transducin 3D structures|Transducin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| + | [[Category: Liu H]] | ||
| + | [[Category: Sun D]] | ||
| + | [[Category: Sun J]] | ||
| + | [[Category: Zhang C]] | ||
Current revision
Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist
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Categories: Homo sapiens | Large Structures | Mus musculus | Liu H | Sun D | Sun J | Zhang C
