1fxz

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[[Image:1fxz.gif|left|200px]]
 
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==CRYSTAL STRUCTURE OF SOYBEAN PROGLYCININ A1AB1B HOMOTRIMER==
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The line below this paragraph, containing "STRUCTURE_1fxz", creates the "Structure Box" on the page.
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<StructureSection load='1fxz' size='340' side='right'caption='[[1fxz]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fxz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Glycine_max Glycine max]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FXZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fxz OCA], [https://pdbe.org/1fxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fxz RCSB], [https://www.ebi.ac.uk/pdbsum/1fxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fxz ProSAT]</span></td></tr>
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{{STRUCTURE_1fxz| PDB=1fxz | SCENE= }}
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</table>
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== Function ==
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'''CRYSTAL STRUCTURE OF SOYBEAN PROGLYCININ A1AB1B HOMOTRIMER'''
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[https://www.uniprot.org/uniprot/GLYG1_SOYBN GLYG1_SOYBN] Glycinin is the major seed storage protein of soybean.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Soybean glycinin is a member of the 11 S globulin family. The crystal structure of proglycinin was determined by X-ray crystallography at 2.8 A resolution with an R-factor of 0.199 and a free R-factor of 0.250. A trimer molecule was found in an asymmetric unit of crystals. The trimer model contains three A1aB1b subunits and comprises 1128 amino acid residues and 34 water molecules. The constituent protomers of the homo-trimeric protein are arranged around a 3-fold symmetry axis with dimensions of 95 Ax95 Ax40 A. The protomer model is composed of five fragments which correspond roughly to conserved regions based on the sequence alignment of various 11 S globulins. The core of the protomer consists of two jelly-roll beta-barrels and two extended helix domains. This structure of proglycinin is similar to those of canavalin and phaseolin belonging to the 7 S globulin family, strongly supporting the hypothesis that both 7 S and 11 S globulins are derived from a common ancestor. The inter and intra-chain disulfide bonds conserved in the 11 S globulin family are clearly observed. It is found that the face with the inter-chain disulfide bond (IE face) contains more hydrophobic residues than that with the intra-chain disulfide bond. This suggests that a mature hexamer is formed by the interaction between the IE faces after processing.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/1fxz_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1FXZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Glycine_max Glycine max]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FXZ OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fxz ConSurf].
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Crystal structure of soybean proglycinin A1aB1b homotrimer., Adachi M, Takenaka Y, Gidamis AB, Mikami B, Utsumi S, J Mol Biol. 2001 Jan 12;305(2):291-305. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11124907 11124907]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Glycine max]]
[[Category: Glycine max]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Adachi, M.]]
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[[Category: Adachi M]]
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[[Category: Gidamis, A B.]]
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[[Category: Gidamis AB]]
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[[Category: Mikami, B.]]
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[[Category: Mikami B]]
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[[Category: Takenaka, Y.]]
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[[Category: Takenaka Y]]
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[[Category: Utsumi, S.]]
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[[Category: Utsumi S]]
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[[Category: Glycinin]]
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[[Category: Legumin]]
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[[Category: Proglycinin]]
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[[Category: Seed storage protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:53:25 2008''
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Current revision

CRYSTAL STRUCTURE OF SOYBEAN PROGLYCININ A1AB1B HOMOTRIMER

PDB ID 1fxz

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