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2eoc
From Proteopedia
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==Solution structure of the WGR domain from human poly [ADP-ribose] polymerase-3== | ==Solution structure of the WGR domain from human poly [ADP-ribose] polymerase-3== | ||
| - | <StructureSection load='2eoc' size='340' side='right'caption='[[2eoc | + | <StructureSection load='2eoc' size='340' side='right'caption='[[2eoc]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2eoc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EOC FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eoc OCA], [https://pdbe.org/2eoc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eoc RCSB], [https://www.ebi.ac.uk/pdbsum/2eoc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eoc ProSAT], [https://www.topsan.org/Proteins/RSGI/2eoc TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eoc OCA], [https://pdbe.org/2eoc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eoc RCSB], [https://www.ebi.ac.uk/pdbsum/2eoc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eoc ProSAT], [https://www.topsan.org/Proteins/RSGI/2eoc TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Hayashi | + | [[Category: Hayashi F]] |
| - | [[Category: Nagashima | + | [[Category: Nagashima T]] |
| - | + | [[Category: Yokoyama S]] | |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution structure of the WGR domain from human poly [ADP-ribose] polymerase-3
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