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2zjn
From Proteopedia
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<StructureSection load='2zjn' size='340' side='right'caption='[[2zjn]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='2zjn' size='340' side='right'caption='[[2zjn]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2zjn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2zjn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZJN FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F1N:N-{1-[5-CHLORO-3-METHOXY-2-(1-METHYLETHOXY)BENZYL]PIPERIDIN-4-YL}-2-(2-METHYL-4-SULFAMOYLPHENOXY)ACETAMIDE'>F1N</scene></td></tr> | |
| - | <tr id=' | + | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjn OCA], [https://pdbe.org/2zjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zjn RCSB], [https://www.ebi.ac.uk/pdbsum/2zjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zjn ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjn OCA], [https://pdbe.org/2zjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zjn RCSB], [https://www.ebi.ac.uk/pdbsum/2zjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zjn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Fahr BT]] | |
| - | [[Category: Fahr | + | [[Category: Lam MB]] |
| - | [[Category: Lam | + | [[Category: Randal M]] |
| - | [[Category: Randal | + | [[Category: Romanowski MJ]] |
| - | [[Category: Romanowski | + | |
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Current revision
Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(2-methyl-4-sulfamoyl-phenoxy)-acetamide
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