2zqk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:40, 6 November 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='2zqk' size='340' side='right'caption='[[2zqk]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='2zqk' size='340' side='right'caption='[[2zqk]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2zqk]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZQK FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2zqk]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZQK FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zwk|2zwk]]</div></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">intimin adherence protein 747-934 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57]), Tir 269-336 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zqk OCA], [https://pdbe.org/2zqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zqk RCSB], [https://www.ebi.ac.uk/pdbsum/2zqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zqk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zqk OCA], [https://pdbe.org/2zqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zqk RCSB], [https://www.ebi.ac.uk/pdbsum/2zqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zqk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/EAE_ECO57 EAE_ECO57]] Necessary for the production of attaching and effacing lesions on tissue culture cells. [[https://www.uniprot.org/uniprot/TIR_ECO57 TIR_ECO57]] Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion. In strain EDL933, acts via the effector protein EspF(U), in a phosphotyrosine- and NCK-independent manner. Tir binds to host BAIAP2, which mediates association with EspF(U) and leads to stimulation of actin polymerization.<ref>PMID:10225900</ref> <ref>PMID:14764108</ref> <ref>PMID:16922867</ref> <ref>PMID:17521329</ref>
+
[https://www.uniprot.org/uniprot/EAE_ECO57 EAE_ECO57] Necessary for the production of attaching and effacing lesions on tissue culture cells.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 15: Line 14:
<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zq/2zqk_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zq/2zqk_consurf.spt"</scriptWhenChecked>
-
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zqk ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zqk ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
-
== References ==
 
-
<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Eco57]]
+
[[Category: Escherichia coli O157:H7]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Gao, F]]
+
[[Category: Gao F]]
-
[[Category: Gao, G F]]
+
[[Category: Gao GF]]
-
[[Category: Li, D F]]
+
[[Category: Li D-F]]
-
[[Category: Ma, Y]]
+
[[Category: Ma Y]]
-
[[Category: Cell adhesion]]
+
-
[[Category: Cell membrane]]
+
-
[[Category: Cell outer membrane]]
+
-
[[Category: Membrane]]
+
-
[[Category: Protein-protein complex]]
+
-
[[Category: Receptor]]
+
-
[[Category: Transmembrane]]
+
-
[[Category: Unique intimin-tir trimer intermediate]]
+
-
[[Category: Virulence]]
+

Current revision

Crystal structure of intimin-Tir68 complex

PDB ID 2zqk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2zqk"
Personal tools