1fyg

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[[Image:1fyg.jpg|left|200px]]
 
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==Solution structure of omega conotoxin SO3 determined by 1H-NMR==
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The line below this paragraph, containing "STRUCTURE_1fyg", creates the "Structure Box" on the page.
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<StructureSection load='1fyg' size='340' side='right'caption='[[1fyg]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fyg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyg OCA], [https://pdbe.org/1fyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyg RCSB], [https://www.ebi.ac.uk/pdbsum/1fyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyg ProSAT]</span></td></tr>
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{{STRUCTURE_1fyg| PDB=1fyg | SCENE= }}
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</table>
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== Function ==
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'''Solution structure of omega conotoxin SO3 determined by 1H-NMR'''
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[https://www.uniprot.org/uniprot/O16O3_CONST O16O3_CONST] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This peptide selectively targets Cav2.2/CACNA1B (IC(50)=160 nM) voltage-gated calcium channels (PubMed:26344359). When tested in mammals, this toxin displays an analgesic potency similar to MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects (tremor, diminution of spontaneous locomotor activity and bad coordinated locomotion) compared with identical dosages of MVIIA injected intrathecally.<ref>PMID:15880145</ref> <ref>PMID:26344359</ref>
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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1FYG is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYG OCA].
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Conus striatus]]
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[[Category: Yan, Y.]]
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[[Category: Large Structures]]
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[[Category: Zhang, R.]]
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[[Category: Yan Y]]
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[[Category: Beta sheet]]
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[[Category: Zhang R]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:54:30 2008''
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Current revision

Solution structure of omega conotoxin SO3 determined by 1H-NMR

PDB ID 1fyg

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