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7t7s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==R-27 in Complex with S. aureus DHFR and tricyclic-NADPH (tNADPH)== | |
| - | + | <StructureSection load='7t7s' size='340' side='right'caption='[[7t7s]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7t7s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=06U:6-ETHYL-5-{(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>06U</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=XNP:TRICYCLIC+NADPH'>XNP</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7s OCA], [https://pdbe.org/7t7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7s RCSB], [https://www.ebi.ac.uk/pdbsum/7t7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Staphylococcus aureus]] | ||
| + | [[Category: Donald BR]] | ||
| + | [[Category: Reeve SM]] | ||
| + | [[Category: Wang S]] | ||
| + | [[Category: Wright DL]] | ||
Current revision
R-27 in Complex with S. aureus DHFR and tricyclic-NADPH (tNADPH)
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