7t6y
From Proteopedia
(Difference between revisions)
(New page: ==d((CGA)5TGA) parallel-stranded homo-duplex== <StructureSection load='7t6y' size='340' side='right'caption='7t6y' scene=''> == Structural highlights == <table><tr><td colspan='2'>Ful...) |
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==d((CGA)5TGA) parallel-stranded homo-duplex== | ==d((CGA)5TGA) parallel-stranded homo-duplex== | ||
| - | <StructureSection load='7t6y' size='340' side='right'caption='[[7t6y]]' scene=''> | + | <StructureSection load='7t6y' size='340' side='right'caption='[[7t6y]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T6Y FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7t6y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=7sb9 7sb9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T6Y FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t6y OCA], [https://pdbe.org/7t6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t6y RCSB], [https://www.ebi.ac.uk/pdbsum/7t6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t6y ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t6y OCA], [https://pdbe.org/7t6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t6y RCSB], [https://www.ebi.ac.uk/pdbsum/7t6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t6y ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | DNA can adopt noncanonical structures that have important biological functions while also providing structural diversity for applications in nanotechnology. Here, the crystal structures of two oligonucleotides composed of d(CGA) triplet repeats in the parallel-stranded duplex form are described. The structure determination of four unique d(CGA)-based parallel-stranded duplexes across two crystal structures has allowed the structural parameters of d(CGA) triplets in the parallel-stranded duplex form to be characterized and established. These results show that d(CGA) units are highly uniform, but that each strand in the duplex is structurally unique and has a distinct role in accommodating structural asymmetries induced by the C-CH(+) base pair. | ||
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| + | The parallel-stranded d(CGA) duplex is a highly predictable structural motif with two conformationally distinct strands.,Luteran EM, Paukstelis PJ Acta Crystallogr D Struct Biol. 2022 Mar 1;78(Pt 3):299-309. doi:, 10.1107/S2059798322000304. Epub 2022 Feb 18. PMID:35234144<ref>PMID:35234144</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7t6y" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
[[Category: Luteran EM]] | [[Category: Luteran EM]] | ||
[[Category: Paukstelis PJ]] | [[Category: Paukstelis PJ]] | ||
Current revision
d((CGA)5TGA) parallel-stranded homo-duplex
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