7vqq
From Proteopedia
(Difference between revisions)
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==Cryo-EM structure of amyloid fibril formed by FUS low complexity domain== | ==Cryo-EM structure of amyloid fibril formed by FUS low complexity domain== | ||
| - | <StructureSection load='7vqq' size='340' side='right'caption='[[7vqq]]' scene=''> | + | <StructureSection load='7vqq' size='340' side='right'caption='[[7vqq]], [[Resolution|resolution]] 2.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VQQ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7vqq]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VQQ FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vqq OCA], [https://pdbe.org/7vqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vqq RCSB], [https://www.ebi.ac.uk/pdbsum/7vqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vqq ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vqq OCA], [https://pdbe.org/7vqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vqq RCSB], [https://www.ebi.ac.uk/pdbsum/7vqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vqq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | FUS is a multifunctional nuclear protein which undergoes liquid-liquid phase separation in response to stress and DNA damage. Dysregulation of FUS dynamic phase separation leads to formation of pathological fibril closely associated with neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal dementia. In this study, we determined the cryo-EM structure of a cytotoxic fibril formed by the low-complexity (LC) domain of FUS at 2.9 A resolution. The fibril structure exhibits a new and extensive serpentine fold consisting of three motifs incorporating together via a Tyr triad. FUS LC employs 91 residues to form an enlarged and stable fibril core via hydrophilic interaction and hydrogen bonds, which is distinct from most of previously determined fibrils commonly stabilized by hydrophobic interaction. Our work reveals the structural basis underlying formation of a cytotoxic and thermostable fibril of FUS LC and sheds light on understanding the liquid-to-solid phase transition of FUS in disease. | ||
| + | |||
| + | Molecular structure of an amyloid fibril formed by FUS low-complexity domain.,Sun Y, Zhang S, Hu J, Tao Y, Xia W, Gu J, Li Y, Cao Q, Li D, Liu C iScience. 2021 Dec 27;25(1):103701. doi: 10.1016/j.isci.2021.103701. eCollection , 2022 Jan 21. PMID:35036880<ref>PMID:35036880</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7vqq" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Liu C]] | + | [[Category: Liu, C]] |
| - | [[Category: Sun | + | [[Category: Sun, Y P]] |
| - | [[Category: Xia | + | [[Category: Xia, W C]] |
| + | [[Category: Amyloid fibril]] | ||
| + | [[Category: Protein fibril]] | ||
Current revision
Cryo-EM structure of amyloid fibril formed by FUS low complexity domain
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