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2zz8

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<StructureSection load='2zz8' size='340' side='right'caption='[[2zz8]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
<StructureSection load='2zz8' size='340' side='right'caption='[[2zz8]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2zz8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"leptospira_icteroides"_noguchi_1919 "leptospira icteroides" noguchi 1919]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZZ8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2zz8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leptospira_interrogans Leptospira interrogans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZZ8 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lipl32 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=173 "Leptospira icteroides" Noguchi 1919])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zz8 OCA], [https://pdbe.org/2zz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zz8 RCSB], [https://www.ebi.ac.uk/pdbsum/2zz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zz8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zz8 OCA], [https://pdbe.org/2zz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zz8 RCSB], [https://www.ebi.ac.uk/pdbsum/2zz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zz8 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/O34094_LEPIN O34094_LEPIN]
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Spirochetes of the genus Leptospira cause leptospirosis in humans and animals worldwide. Proteins exposed on the bacterial cell surface are implicated in the pathogenesis of leptospirosis. However, the biological role of the majority of these proteins is unknown; this is principally due to the lack of genetic systems for investigating Leptospira and the absence of any structural information on leptospiral antigens. To address this, we have determined the 2.0-A-resolution structure of the lipoprotein LipL32, the most abundant outer-membrane and surface protein present exclusively in pathogenic Leptospira species. The extracellular domain of LipL32 revealed a compact, globular, "jelly-roll" fold from which projected an unusual extended beta-hairpin that served as a principal mediator of the observed crystallographic dimer. Two acid-rich patches were also identified as potential binding sites for positively charged ligands, such as laminin, to which LipL32 has a propensity to bind. Although LipL32 shared no significant sequence identity to any known protein, it possessed structural homology to the adhesins that bind components of the extracellular matrix, suggesting that LipL32 functions in an analogous manner. Moreover, the structure provides a framework for understanding the immunological role of this major surface lipoprotein.
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Crystal structure of LipL32, the most abundant surface protein of pathogenic Leptospira spp.,Vivian JP, Beddoe T, McAlister AD, Wilce MC, Zaker-Tabrizi L, Troy S, Byres E, Hoke DE, Cullen PA, Lo M, Murray GL, Adler B, Rossjohn J J Mol Biol. 2009 Apr 17;387(5):1229-38. Epub 2009 Feb 21. PMID:19236879<ref>PMID:19236879</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2zz8" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Leptospira icteroides noguchi 1919]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Beddoe, T]]
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[[Category: Leptospira interrogans]]
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[[Category: Rossjohn, J]]
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[[Category: Beddoe T]]
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[[Category: Vivian, J P]]
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[[Category: Rossjohn J]]
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[[Category: Leptospira]]
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[[Category: Vivian JP]]
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[[Category: Outer-membrane protein]]
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[[Category: Unknown function]]
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Current revision

Crystal structure of LipL32, the most abundant surface protein of pathogenic leptospira spp

PDB ID 2zz8

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