Inhibitory neurosteroids

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(New page: <StructureSection load='5osb' size='340' side='right' caption=''> This is a default text for your page '''Inhibitory neurosteroids'''. Click above on '''edit this page''' to modify. Be car...)
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<StructureSection load='5osb' size='340' side='right' caption=''>
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<StructureSection load='5osb' size='340' side='right' caption='Mouse GLIC-GABAA receptor complex with corticosterone derivative, acetate and Cl- ion (PDB code [[5osb]])'>
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This is a default text for your page '''Inhibitory neurosteroids'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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These [[neurosteroids]] exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the [[GABAA receptor]] (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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== Function ==
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Major examples include <scene name='89/896619/Cv/7'>tetrahydrodeoxycorticosterone</scene> (THDOC; from [[5osb]]), the androstane 3α-androstanediol, the cholestane cholesterol and the pregnanes pregnanolone (eltanolone), allopregnanolone (3α,5α-THP).
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== Disease ==
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== Relevance ==
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== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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</StructureSection>
</StructureSection>
== References ==
== References ==
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Current revision

Mouse GLIC-GABAA receptor complex with corticosterone derivative, acetate and Cl- ion (PDB code 5osb)

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References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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