1g29

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[[Image:1g29.jpg|left|200px]]
 
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==MALK==
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The line below this paragraph, containing "STRUCTURE_1g29", creates the "Structure Box" on the page.
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<StructureSection load='1g29' size='340' side='right'caption='[[1g29]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1g29]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_litoralis Thermococcus litoralis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G29 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
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{{STRUCTURE_1g29| PDB=1g29 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g29 OCA], [https://pdbe.org/1g29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g29 RCSB], [https://www.ebi.ac.uk/pdbsum/1g29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g29 ProSAT]</span></td></tr>
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</table>
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'''MALK'''
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== Function ==
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[https://www.uniprot.org/uniprot/MALK_THELN MALK_THELN] Part of the ABC transporter complex MalEFGK involved in trehalose/maltose import. Responsible for energy coupling to the transport system.<ref>PMID:10400644</ref> <ref>PMID:11453995</ref> <ref>PMID:8759837</ref>
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The members of the ABC transporter family transport a wide variety of molecules into or out of cells and cellular compartments. Apart from a translocation pore, each member possesses two similar nucleoside triphosphate-binding subunits or domains in order to couple the energy-providing reaction with transport. In the maltose transporter of several Gram-negative bacteria and the archaeon Thermo coccus litoralis, the nucleoside triphosphate-binding subunit contains a C-terminal regulatory domain. A dimer of the subunit is attached cytoplasmically to the translocation pore. Here we report the crystal structure of this dimer showing two bound pyrophosphate molecules at 1.9 A resolution. The dimer forms by association of the ATPase domains, with the two regulatory domains attached at opposite poles. Significant deviation from 2-fold symmetry is seen at the interface of the dimer and in the regions corresponding to those residues known to be in contact with the translocation pore. The structure and its relationship to function are discussed in the light of known mutations from the homologous Escherichia coli and Salmonella typhimurium proteins.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/1g29_consurf.spt"</scriptWhenChecked>
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1G29 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermococcus_litoralis Thermococcus litoralis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G29 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis., Diederichs K, Diez J, Greller G, Muller C, Breed J, Schnell C, Vonrhein C, Boos W, Welte W, EMBO J. 2000 Nov 15;19(22):5951-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11080142 11080142]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g29 ConSurf].
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[[Category: Single protein]]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermococcus litoralis]]
[[Category: Thermococcus litoralis]]
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[[Category: Boos, W.]]
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[[Category: Boos W]]
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[[Category: Breed, J.]]
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[[Category: Breed J]]
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[[Category: Diederichs, K.]]
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[[Category: Diederichs K]]
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[[Category: Diez, J.]]
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[[Category: Diez J]]
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[[Category: Greller, G.]]
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[[Category: Greller G]]
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[[Category: Mueller, C.]]
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[[Category: Mueller C]]
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[[Category: Schnell, C.]]
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[[Category: Schnell C]]
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[[Category: Vonrhein, C.]]
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[[Category: Vonrhein C]]
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[[Category: Welte, W.]]
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[[Category: Welte W]]
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[[Category: Active transport]]
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[[Category: Atpase]]
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[[Category: Maltose uptake and regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:02:42 2008''
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Current revision

MALK

PDB ID 1g29

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