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3bc3

From Proteopedia

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Current revision (12:06, 30 August 2023) (edit) (undo)
 
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<StructureSection load='3bc3' size='340' side='right'caption='[[3bc3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3bc3' size='340' side='right'caption='[[3bc3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3bc3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BC3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3bc3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BC3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OPT:S-BENZYL-N-(BIPHENYL-4-YLACETYL)-L-CYSTEINYL-N~5~-(DIAMINOMETHYL)-D-ORNITHYL-N-(2-PHENYLETHYL)-L-TYROSINAMIDE'>OPT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=OPT:S-BENZYL-N-(BIPHENYL-4-YLACETYL)-L-CYSTEINYL-N~5~-(DIAMINOMETHYL)-D-ORNITHYL-N-(2-PHENYLETHYL)-L-TYROSINAMIDE'>OPT</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mhw|1mhw]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bc3 OCA], [https://pdbe.org/3bc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bc3 RCSB], [https://www.ebi.ac.uk/pdbsum/3bc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bc3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bc3 OCA], [https://pdbe.org/3bc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bc3 RCSB], [https://www.ebi.ac.uk/pdbsum/3bc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bc3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes.
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[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cathepsin L]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bhat, S]]
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[[Category: Bhat S]]
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[[Category: Chowdhury, S F]]
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[[Category: Chowdhury SF]]
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[[Category: Joseph, L]]
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[[Category: Joseph L]]
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[[Category: Kumar, S]]
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[[Category: Kumar S]]
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[[Category: Nard, R M]]
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[[Category: Nard RM]]
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[[Category: Purisima, E O]]
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[[Category: Purisima EO]]
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[[Category: Sivaraman, J]]
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[[Category: Sivaraman J]]
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[[Category: Tulsidas, S R]]
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[[Category: Tulsidas SR]]
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[[Category: Ziomek, E]]
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[[Category: Ziomek E]]
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[[Category: Cathepsin l inhibitor binding at the s subsite]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Lysosome]]
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[[Category: Protease]]
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[[Category: Thiol protease]]
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[[Category: Zymogen]]
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Current revision

Exploring inhibitor binding at the S subsites of cathepsin L

PDB ID 3bc3

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OCA

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