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7t3l
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of Csy-AcrIF24-DNA dimer== | |
| - | + | <StructureSection load='7t3l' size='340' side='right'caption='[[7t3l]], [[Resolution|resolution]] 3.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7t3l]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia Escherichia] and [https://en.wikipedia.org/wiki/Pseudomonas Pseudomonas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T3L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t3l OCA], [https://pdbe.org/7t3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t3l RCSB], [https://www.ebi.ac.uk/pdbsum/7t3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t3l ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Chang | + | [https://www.uniprot.org/uniprot/CSY1_PSEAB CSY1_PSEAB] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 and Cascade participate in CRISPR interference, the third stage of CRISPR immunity (Potential). Involved in crRNA production or stability. The Csy ribonucleoprotein complex binds target ssDNA with high affinity but target dsDNA with much lower affinity.<ref>PMID:21398535</ref> <ref>PMID:22522703</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas]] | ||
| + | [[Category: Chang L]] | ||
| + | [[Category: Mukherjee IA]] | ||
Current revision
Cryo-EM structure of Csy-AcrIF24-DNA dimer
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