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2x7n

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Current revision (10:21, 9 May 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2x7n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X7N FirstGlance]. <br>
<table><tr><td colspan='2'>[[2x7n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X7N FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1k5y|1k5y]], [[1g62|1g62]], [[1s1i|1s1i]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 11.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7n OCA], [https://pdbe.org/2x7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x7n RCSB], [https://www.ebi.ac.uk/pdbsum/2x7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7n OCA], [https://pdbe.org/2x7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x7n RCSB], [https://www.ebi.ac.uk/pdbsum/2x7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/IF6_YEAST IF6_YEAST]] Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by the GTPase RIA1/EFL1 and by SDO1. Also required for pre-rRNA processing.<ref>PMID:10085284</ref> <ref>PMID:11779510</ref> <ref>PMID:11238882</ref> <ref>PMID:17353896</ref> <ref>PMID:18256024</ref> <ref>PMID:11101899</ref>
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[https://www.uniprot.org/uniprot/RL23A_YEAST RL23A_YEAST]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Armache, J P]]
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[[Category: Armache J-P]]
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[[Category: Beckmann, R]]
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[[Category: Beckmann R]]
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[[Category: Blau, M]]
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[[Category: Blau M]]
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[[Category: Gartmann, M]]
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[[Category: Gartmann M]]
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[[Category: Mielke, T]]
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[[Category: Mielke T]]
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[[Category: Topf, M]]
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[[Category: Topf M]]
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[[Category: Initiation factor]]
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[[Category: Protein biosynthesis]]
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[[Category: Ribonucleoprotein]]
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[[Category: Ribosomal protein]]
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[[Category: Ribosomal protein-rna complex]]
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Current revision

Mechanism of eIF6s anti-association activity

2x7n, resolution 11.80Å

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OCA

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